Tinidazole in the treatment of infections of the upper respiratory tract.
Tinidazole in the treatment of infections of the upper respiratory tract.
复制标题
替硝唑用于治疗上呼吸道感染。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
C. Nord
中科院分区：
文献类型：
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作者：
C. Lundberg;J. Lönnroth;G. Marklund;C. Nord
用替硝唑治疗16例原发性或继发性上颌窦、口腔和咽喉厌氧菌感染。8名患者最初给予2 g替硝唑，随后5天每天给予1 g替硝唑，第一天的血浆峰浓度在15至48 μ g/ml之间变化，在随后的几天内仅略低。混合唾液/血浆浓度比范围为0.2 - 1.8，平均值为0.85。在8例患有心绞痛性传染性单核细胞增多症的患者中，在治疗开始后观察到迅速改善。在3至5天内恢复正常体温和健康。从这些患者中未分离出与咽喉感染相关的细菌，因此，似乎不太可能仅将临床获益归因于替硝唑的抗菌活性。五例化脓性上颌窦炎、两例萎缩性咽炎急性加重和一例舌坏死性溃疡患者的厌氧菌感染用替硝唑成功治疗。
Sixteen patients with primary or secondary anaerobic infections of the maxillary sinus, mouth and throat were treated with tinidazole. The peak plasma concentration in eight patients given 2 g tinidazole initially followed by 1 g daily on the 5 subsequent days varied between 15 and 48 microgram/ml the first day and were only slightly lower during the following days. The mixed saliva/plasma concentration ratios ranged between 0.2 and 1.8 with a mean value of 0.85. In eight patients with anginose infectious mononucleosis, a rapid improvement was observed after the onset of treatment. Normal body temperature and well-being was restored within 3 to 5 days. No bacteria considered to be involved in the infection of the throat were isolated from these patients, and it, therefore, seems unlikely that the clinical benefit is attributable only to antibacterial activity of tinidazole. Anaerobic infections in five patients with purulent maxillary sinusitis, two patients with acute exacerbation of atrophic pharyngitis and one patient with a necrotic ulcer of the tongue, were treated successfully with tinidazole.