Cloning and expression pattern of lbx3, a novel chick homeobox gene
Cloning and expression pattern of lbx3, a novel chick homeobox gene
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新型小鸡同源基因 lbx3 的克隆和表达模式
DOI：
10.1016/j.modgep.2005.08.004
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发表时间：
2006-03-01
影响因子：
1.2
通讯作者：
Furukawa, T
中科院分区：
文献类型：
--
作者：
Kanamoto, T;Terada, K;Furukawa, T
黑腹果蝇（Drosophilamelanogaster）的早瓢虫基因（lbe）和晚瓢虫基因（lbl）编码转录调控因子，其在神经发生、肌肉发生和心脏发生中起重要作用。在这里，我们报告了一种新型瓢虫家族同源盒基因（lbx 3）的分离及其在小鸡发育过程中的表达。lbx3的开放阅读框架编码一个213个氨基酸的蛋白质，包括一个同源结构域，一个PST基序和一个核定位信号。lbx3蛋白的同源结构域与鸡和小鼠lbx1同源结构域的同源性为80%，与小鼠lbx2同源结构域的同源性为75%。lbx1和lbx3在颈部和肢体水平的预期轴下成肌细胞中表达。此外，在第23期所有轴向水平的体节的内侧dermomyotomal唇中检测到lbx3转录物，但在神经管中未检测到。(C)2005 Elsevier B.V.保留所有权利。
The Drosophila melanogaster genes, ladybird early (lbe) and ladybird late (lbl), encode transcriptional regulators, which play an important role in neurogenesis, myogenesis and cardiogenesis. Here, we report an isolation of a novel ladybird family homeobox gene (lbx3) and its expression during chick development. The open reading frame of lbx3 encodes a predicted protein of 213 amino acids including a homeodomain, a PST motif and a nuclear localization signal. The homeodomain of lbx3 protein has 80% identities with the chick and mouse lbx1 homeodomains, and 75% identity with the mouse lbx2, homeodomain. Both lbx1 and lbx3 are expressed in prospective hypaxial myoblasts at cervical and limb level. In addition, lbx3 transcripts are detected in the medial dermomyotomal lips of somites of all axial levels at stage 23, but not detected in the neural tube. (C) 2005 Elsevier B.V. All rights reserved.