Effects of chewing and swallowing behavior on jaw opening reflex responses in naturally feeding rabbits
Effects of chewing and swallowing behavior on jaw opening reflex responses in naturally feeding rabbits
复制标题
咀嚼和吞咽行为对自然喂养兔张颌反射反应的影响
DOI：
10.1016/j.neulet.2012.12.047
复制
发表时间：
2013
影响因子：
2.5
通讯作者：
Aki Yamada
中科院分区：
文献类型：
--
作者：
Saitoh I;Sato M;Iwase Y;Akasaka E;Yamasaki Y;Noguchi H;Aki Yamada
据报道，口腔内无害刺激诱发的下颌张开反射（JOR）仅在麻醉动物的反射性吞咽过程中受到抑制。然而，吞咽过程中JOR抑制的机制尚未阐明。本研究的目的是探讨周围神经刺激对咀嚼行为的影响，以及低阈值传入诱发的JOR反应的调制在自由进食动物咀嚼和吞咽。低阈值电刺激下牙槽神经（IAN）诱发二腹肌JOR。在咀嚼和吞咽的相位之间的二腹肌肌电图反应的峰-峰幅度的变化进行了比较。IAN刺激在周期持续时间、一个周期中的下颌张开或吞咽间隔方面没有产生任何差异，这表明对进食行为的影响极小。咀嚼的快闭、慢闭和慢开阶段的JOR幅度显著小于对照（在动物休息时记录）和快开阶段。在吞咽过程中，JOR幅度显著小于对照组。在吞咽过程中抑制JOR被认为是为了防止不必要的反向下颌张开运动。
It has been reported that the jaw opening reflex (JOR) evoked by intra-oral innocuous stimulation was suppressed during a reflex swallow in anesthetized animals only. However, the mechanism of JOR inhibition during swallowing has not yet been elucidated. The aim of the present study was to investigate the effects of peripheral nerve stimulation on masticatory behaviors, as well as the modulation of low threshold afferent evoked JOR responses during chewing and swallowing in freely feeding animals. The JOR in the digastric muscle was evoked by low threshold electrical stimulation of the inferior alveolar nerve (IAN). Changes in the peak-to-peak amplitude of digastric electromyographic responses were compared among the phases of chewing and swallowing. IAN stimulation did not produce any differences in cycle duration, gape of the jaw in one cycle, or swallowing interval, suggesting a minimal effect on feeding behaviors. The JOR amplitude during the fast-closing, slow-closing, and slow-opening phases of chewing was significantly smaller than that of the control (recorded when the animal was at rest) and fast-opening phase. During swallowing, the JOR amplitude was significantly less than the control. Inhibition of the JOR during swallowing is assumed to prevent unnecessary opposing jaw opening motion.