T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis
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DOI：
10.1111/j.0902-0055.2004.00134.x
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发表时间：
2004-06-01
影响因子：
--
通讯作者：
Seymour, GJ
中科院分区：
文献类型：
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作者：
Yamazaki, K;Ohsawa, Y;Seymour, GJ
据报道，牙周炎患者患冠心病的风险显著增加。研究表明，对热休克蛋白60（HSP 60）的免疫应答可能参与了动脉粥样硬化和慢性牙周炎的发病机制。为了研究这些疾病之间可能存在的联系，将动脉粥样硬化患者对HSP 60的细胞和体液免疫应答与牙周炎患者和健康受试者使用人和牙龈卟啉单胞菌HSP 60（GroEL）作为抗原进行了比较。抗人和牙龈卟啉单胞菌HSP60的抗体水平在动脉粥样硬化患者中最高，其次是牙周炎患者和健康受试者。T细胞的克隆分析清楚地表明，动脉粥样硬化患者的外周循环中不仅存在人HSP 60反应性T细胞群，而且存在牙龈卟啉单胞菌GroEL反应性T细胞群。此外，这些HSP 60反应性T细胞似乎存在于一些患者的动脉粥样硬化病变中。这些结果表明，具有相同特异性的T细胞克隆可能参与不同疾病的发病机制。
Individuals with periodontitis have been reported to have a significantly increased risk of developing coronary heart disease. Several studies have demonstrated that the immune response to heat shock protein 60 (HSP60) may be involved in the pathogenesis of both atherosclerosis and chronic periodontitis. To investigate this possible link between these diseases, cellular and humoral immune responses to HSP60 in atherosclerosis patients were compared with those in periodontitis patients and healthy subjects using human and Porphyromonas gingivalis HSP60 (GroEL) as antigens. Antibody levels to both human and P. gingivalis HSP60s were the highest in atherosclerosis patients, followed by periodontitis patients and healthy subjects. Clonal analysis of the T cells clearly demonstrated the presence of not only human HSP60- but also P. gingivalis GroEL-reactive T-cell populations in the peripheral circulation of atherosclerosis patients. Furthermore, these HSP60-reactive T cells seemed to be present in atherosclerotic lesions in some patients. These results suggest that T-cell clones with the same specificity may be involved in the pathogenesis of the different diseases.