Mechanical and chemical analysis of gelatin-based hydrogel degradation
Mechanical and chemical analysis of gelatin-based hydrogel degradation
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DOI：
10.1002/macp.200350042
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发表时间：
2003-10-16
影响因子：
2.5
通讯作者：
Kao, WYJ
中科院分区：
文献类型：
--
作者：
Martínez-Díaz, GJ;Nelson, D;Kao, WYJ
研究了环境pH值、温度、明胶主链改性及含量对明胶/聚乙二醇二丙烯酸酯（PEGdA）互穿网络（IPN）拉伸性能和降解性能的影响。无论是增加PEGdA含量或改性明胶骨架与PEG-单乙酸酯和/或聚阴离子在室温下（rt）的IPN弹性降低。在不同pH值和温度的水环境下，IPN拉伸性能的降解进一步加速。与戊二醛固定的明胶水凝胶相比，IPN显示出增强的弹性和强度。在水溶液条件下，互穿聚合物网络表现出更广泛的降解产物比水凝胶交联与戊二醛，其特征在于与凝胶渗透色谱。IPN降解产物的性质与明胶骨架改性的类型无关。负载药物氯己定二葡萄糖酸盐的存在，发现其与改性明胶骨架的PEG-单乙酸酯相互作用，导致独特的降解产物。IPNs的拉伸和化学降解是环境条件、时间和材料改性的复杂相互关系。
The interrelated effect of environmental pH and temperature, gelatin backbone modification and content on the tensile and degradative property of interpenetrating nets works (IPNs) containing gelatin and poly(ethylene glycol) diacrylate (PEGdA) was examined. Either increasing the PEGdA content or modifying the gelatin backbone with PEG-monoacetate ester and/or polyanions decreased the IPN elasticity at ambient room temperature (rt). Under an aqueous environment of varying pH levels and elevated temperature, the degradation of IPN tensile properties was further accelerated. IPNs showed an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. Under an aqueous condition, IPNs showed a wider range of degradation products than hydrogels cross-linked with glutaraldehyde, as characterized with gel permeation chromatography. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The presence of loaded drug, chlorohexidine digluconate, which was found to interact with PEG-monoacetate esters of the modified gelatin backbone, resulted in unique degradation products. The tensile and chemical degradation of IPNs is a complex interrelationship of the environmental condition, time, and material modification.