Transformation of C3H 10T1/2 cells with 4.3 MeV alpha particles at low doses: effects of single and fractionated doses.
Transformation of C3H 10T1/2 cells with 4.3 MeV alpha particles at low doses: effects of single and fractionated doses.
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低剂量 4.3 MeV α 粒子对 C3H 10T1/2 细胞的转化：单剂量和分次剂量的影响。
DOI：
10.2307/3578318
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发表时间：
1992
影响因子：
3.4
通讯作者：
L. Tallone
中科院分区：
文献类型：
--
作者：
D. Bettega;P. Calzolari;G. N. Chiorda;L. Tallone
用4.3 MeVα粒子照射C3H10T1/2细胞，观察不同剂量的α粒子对C3H10T1/2细胞的致癌作用。阿尔法粒子的来源是244Cm，辐射是在为此目的而建造的辐射室中进行的。研究了0.2到300cGy值范围内的分级剂量，特别强调了低剂量区，在最高10cGy值的间隔内有多达7个点。剂量-效应关系是一个复杂的函数。转化频率随剂量增加而增加；在2~20cGy剂量范围内，转化频率趋于平缓，但在较高剂量时又有所增加。单次照射或分3次或10次等剂量照射，间隔1.5h。两种分割方案的剂量-延长效应倒数均为1.4。对不同组分之前的群体有丝分裂指数的测量表明，即使在极低剂量的辐射后，细胞分裂速度也会受到强烈的影响。有丝分裂产率随总剂量的增加而显著降低，两种分割方案的分裂产率分别为4.2cGy值的50%和14cGy值的20%。
Oncogenic transformation of C3H 10T1/2 cells was determined after exposure to graded doses of 4.3-MeV alpha particles LET = 101 keV/microns. The source of alpha particles was 244Cm and the irradiation was done in an irradiation chamber built for the purpose. Graded doses in the range of 0.2 to 300 cGy were studied with special emphasis on the low-dose region, with as many as seven points in the interval up to 10 cGy. The dose-effect relationship was a complex function. Transformation frequency increased with dose up to 2 cGy; it seemed to flatten at doses between 2 and 20 cGy but increased again at higher doses. A total of 21 cGy was delivered in a single dose or in 3 or 10 equal fractions at an interval of 1.5 h. An inverse dose-protraction effect of 1.4 was found with both fractionation schemes. Measurements of the mitotic index of the population immediately before the various fractions revealed a strong effect on the rate of cell division even after very low doses of radiation. Mitotic yield decreased markedly with the total dose delivered, and it was as low as 50% of the control value after 4.2 cGy and 20% after 14 cGy with both fractionation schemes.
低剂量率的裂变谱中子增强线性低剂量区域（0-10 cGy）的肿瘤转化。
DOI：
10.1080/09553008414551011
发表时间：
1984
期刊：
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子：
--
作者：
Hill,CK;Han,A;Elkind,MM
通讯作者：
Elkind,MM
在小鼠 10T1/2 和 3T3 细胞的密度抑制培养物中，α 粒子诱导染色体畸变和姐妹染色单体交换。
影响因子：
2.6
作者：
Nagasawa,H;Robertson,J;Little,JB
通讯作者：
Little,JB