Synthesis of the unnatural amino acid AGDHE, a constituent of the cyclic depsipeptides callipeltins A and D.
Synthesis of the unnatural amino acid AGDHE, a constituent of the cyclic depsipeptides callipeltins A and D.
复制标题
非天然氨基酸 AGDHE 的合成，它是环状缩酚肽 callipeltins A 和 D 的组成部分。
DOI：
10.1021/ol0269852
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发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Lipton,MarkA
中科院分区：
文献类型：
--
作者：
Thoen,JasonC;Morales-Ramos,AngelI;Lipton,MarkA
以受保护的1-鸟氨酸衍生物为原料，经13步反应(总收率15%)合成了新的氨基酸残基(2R，3R，4S)-4-amido-7-guanidino-2，3-dihydroxyheptanoic酸(AGDHE，3)及其(2S，3S，4S)非对映异构体，并用核磁共振氢谱对其构型进行了重新鉴定。
The novel amino acid residue (2R,3R,4S)-4-amido-7-guanidino-2,3-dihydroxyheptanoic acid (AGDHE,3), a constituent of the cyclic depsipeptides callipeltins A and D, and its (2S,3S,4S) diastereomer were synthesized from a protectedl-ornithine derivative in 13 steps (15% overall yield), and its configurational assignment was reexamined by1H NMR.