Harnessing Janus nanoparticles to create controllable pores in membranes
Harnessing Janus nanoparticles to create controllable pores in membranes
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DOI：
10.1021/nn8000998
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发表时间：
2008-06-01
期刊：
影响因子：
17.1
通讯作者：
Balazs, Anna C.
中科院分区：
文献类型：
--
作者：
Alexeev, Alexander;Uspal, William E.;Balazs, Anna C.
我们使用粗粒度的数值模拟来设计具有稳定孔隙的合成膜，该孔隙可以可控地打开和关闭。具体来说，我们使用耗散粒子动力学探测脂质双层膜和纳米粒子之间的相互作用。所述颗粒是纳米级Janus珠粒，其包含疏水部分和亲水部分。我们证明，当膜撕裂，并形成一个洞，由于外部应力，这些纳米粒子扩散到孔的边缘，并形成一个稳定的孔，它仍然存在后，应力释放。一旦形成颗粒内衬孔，膜张力的小幅增加很容易重新打开孔，允许通过膜运输。除了施加外力，膜张力可以通过改变，例如，温度或pH值。因此，研究结果提供了指导方针，用于设计纳米粒子双层组件的目标交付，其中孔打开和货物被释放，只有当当地的环境条件达到临界值。
We use a coarse-grained numerical simulation to design a synthetic membrane with stable pores that can be controllably opened and closed. Specifically, we use dissipative particle dynamics to probe the interactions between lipid bilayer membranes and nanoparticles. The particles are nanoscopic Janus beads that comprise both hydrophobic and hydrophilic portions. We demonstrate that when the membrane rips and forms a hole due to an external stress, these nanoparticles diffuse to the edge of the hole and form a stable pore, which persists after the stress is released. Once the particle-lined pore is formed, a small increase in membrane tension readily reopens the pore, allowing transport through the membrane. Besides the application of an external force, the membrane tension can be altered by varying, for example, temperature or pH. Thus, the findings provide guidelines for designing nanoparticle-bilayer assemblies for targeted delivery, where the pores open and the cargo is released only when the local environmental conditions reach a critical value.