Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
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DOI：
10.1073/pnas.1003743107
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发表时间：
2010-07-13
影响因子：
11.1
通讯作者：
Schoetz, Eva-Maria
中科院分区：
文献类型：
--
作者：
Manning, M. Lisa;Foty, Ramsey A.;Schoetz, Eva-Maria
在动物形态发生的过程中，会发生大规模的细胞运动，这涉及到细胞群在特定构型中的重排、相互扩散和区室化。形态发生的细胞重排，如细胞分选和相互组织扩散已经与不混溶液体的行为进行了比较，它们非常相似。基于这种相似性，已经提出组织表现为液体并且具有特征表面张力，其作为移动的、粘附的细胞群的集体宏观性质而出现。但是组织表面张力是如何产生的呢？已经提出了不同的理论来解释如何介观细胞特性，如细胞-细胞粘附和细胞界面的收缩性可能是组织表面张力的基础。虽然最近的工作表明，这两个可能是贡献者，一个明确的模型依赖于这些介观参数的组织表面张力一直失踪。在这里，我们明确表明，粘附皮质张力的比例决定组织表面张力。我们的最小模型成功地解释了现有的实验数据，并作出预测，机械能和几何形状之间的反馈的基础上，聚集体表面细胞的形状，我们实验验证。该模型表明，存在从粘附主导到皮质张力主导的行为的交叉，作为这两个量之间的比率的函数。
In the course of animal morphogenesis, large-scale cell movements occur, which involve the rearrangement, mutual spreading, and compartmentalization of cell populations in specific configurations. Morphogenetic cell rearrangements such as cell sorting and mutual tissue spreading have been compared with the behaviors of immiscible liquids, which they closely resemble. Based on this similarity, it has been proposed that tissues behave as liquids and possess a characteristic surface tension, which arises as a collective, macroscopic property of groups of mobile, cohering cells. But how are tissue surface tensions generated? Different theories have been proposed to explain how mesoscopic cell properties such as cell-cell adhesion and contractility of cell interfaces may underlie tissue surface tensions. Although recent work suggests that both may be contributors, an explicit model for the dependence of tissue surface tension on these mesoscopic parameters has been missing. Here we show explicitly that the ratio of adhesion to cortical tension determines tissue surface tension. Our minimal model successfully explains the available experimental data and makes predictions, based on the feedback between mechanical energy and geometry, about the shapes of aggregate surface cells, which we verify experimentally. This model indicates that there is a crossover from adhesion dominated to cortical-tension dominated behavior as a function of the ratio between these two quantities.