PARENCHYMAL ENHANCEMENT AND TUMOR VISUALIZATION USING A NEW SONOGRAPHIC CONTRAST AGENT
PARENCHYMAL ENHANCEMENT AND TUMOR VISUALIZATION USING A NEW SONOGRAPHIC CONTRAST AGENT
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DOI：
10.7863/jum.1995.14.12.949
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发表时间：
1995-12-01
影响因子：
2.3
通讯作者：
GOLDBERG, BB
中科院分区：
文献类型：
--
作者：
FORSBERG, F;LIU, JB;GOLDBERG, BB
本研究的目的是评估超声造影剂增强实质回声性和提高肿瘤可见性的能力。该制剂是一种乳剂，在体温下由无回声的亚微米液滴变为有回声的1至5 μ m微泡，能够穿过肺部和毛细血管循环。对5只土拨鼠（3只多发性肝癌）、12只兔（肾VX-2肿瘤）和4只狗进行外周静脉注射（剂量为0.05 ~ 0.8 ml/kg）。肾、肝、肿瘤（含肿瘤血管）及正常血管超声检查。通过视频密度测定生成摄取和冲洗曲线。最后，分析了腹腔干周围袖带传感器的多普勒频移，以提供体内剂量-反应曲线。血管增强，包括肝癌和VX-2肿瘤血管，可见2至3分钟。0.6 ml/kg剂量的最大增强为18.7 dB。正常肝脏和肾脏实质的强化在所有三种动物中均可观察到长达20分钟。小肝癌中心回声增强，而较大的肿瘤中心回声不增强。总之，在动物中，肿瘤的可见性和实质增强得到了改善。
The purpose of this study was to assess the ability of a sonographic contrast agent to increase parenchymal echogenicity and improve tumor visibility. The agent is an emulsion that changes at body temperature from nonechogenic submicrometer liquid droplets to echogenic 1 to 5 mu m microbubbles, capable of traversing the pulmonary and capillary circulations. Peripheral venous injections (dosages of 0.05 to 0.8 ml/kg) were administered to five woodchucks (three with multiple hepatomas), 12 rabbits (with renal VX-2 tumors), and four dogs. Ultrasonograms were acquired from kidney, liver, tumors (including tumor vessels) and normal vessels. Uptake and washout curves were generated via videodensitometry. Finally, Doppler shifts from a cuff transducer around the celiac trunk were analyzed to provide an in vivo dose-response curve. Vascular enhancement, including hepatoma and VX-2 tumor vessels, was seen for 2 to 3 min. Maximum enhancement was 18.7 dB for a 0.6 ml/kg dose. Enhancement of normal liver and kidney parenchyma was observed in all three species for up to 20 min. Small hepatomas became more echogenic centrally, but larger tumors showed no increase in central echogenicity. In conclusion, improved tumor visibility and parenchymal enhancement was demonstrated in animals.