Evaluation of particle shape, size and magnetic field intensity for targeted delivery efficiency and plaque injury in treating atherosclerosis
Evaluation of particle shape, size and magnetic field intensity for targeted delivery efficiency and plaque injury in treating atherosclerosis
复制标题
评估颗粒形状、大小和磁场强度，以评估治疗动脉粥样硬化的靶向递送效率和斑块损伤
DOI：
10.1016/j.powtec.2020.02.003
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发表时间：
2020-04-15
影响因子：
5.2
通讯作者：
Wang, Erhui
中科院分区：
文献类型：
--
作者：
Zhang, Xuelan;Zheng, Liancun;Wang, Erhui
从靶向递送效率（eta）和斑块损伤方面对磁性纳米颗粒疗法对患者特异性动脉粥样硬化的治疗效果进行了综合评估。采用欧拉-拉格朗日技术，首次引入模拟载药颗粒向斑块靶向递送的创新模型，其中阻力系数C-D考虑了颗粒的形状和尺寸。研究了颗粒形状、尺寸和磁场强度对 eta 和以时空平均剪切应力（(TAWSS) over bar）为特征的斑块损伤的影响。结果表明，在不同形状的转运颗粒的药物递送中，条形上的n和(TAWSS)的顺序为血小板>圆柱体>叶片>球体>砖块，这表明药物靶向能力较高的颗粒可能会引起更大的斑块损伤。此外，研究发现，将粒径从300 nm增加到500 nm或将电流从5E4增加到2E5 A，使eta分别增强近9.3%或18.1%，但这背后对牙菌斑本身的损害更大。与此同时，不同形状颗粒对斑块造成的损伤差异也被放大。获得的结果有可能作为优化动脉粥样硬化靶向治疗的传输粒子和磁场设计的指南。 (C) 2020 Elsevier B.V. 保留所有权利。
A comprehensive evaluation of therapeutic effects of magnetic nanoparticle therapy for patient-specific atherosclerosis is presented in terms of targeted delivery efficiency (eta) and plaque injury. Eulerian-Lagrangian technique is adopted, and an innovative model is first introduced for simulating targeted delivery drug-loaded particles to plaque, in which the shape and size of particles are taken into account in the drag coefficient C-D. The impacts of particle shape, size and magnetic field intensity on eta and plaque injury characterized by temporal-spatial averaged shear stress ((TAWSS) over bar) are investigated. The results signify that, among drug delivery using the transport particles of different shapes, the sequences of n and (TAWSS) over bar are platelet>cylinder>blade>sphere>brick, which indicates that the particle with higher drug targeting ability may induce greater plaque injury. Moreover, it is found that increasing the particle size from 300 to 500 nm or the current from 5E4 to 2E5 A enhances eta by nearly 9.3% or 18.1%, respectively, but behind this are greater damage to plaque itself. Along with this, the injury discrepancy of plaque induced by particles with different shapes is also amplified. Results obtained can potentially serve as the guideline to optimize the design of transport particle and magnetic field for targeted therapy to atherosclerosis. (C) 2020 Elsevier B.V. All rights reserved.