Data on the mechanobiological differences in the transcriptomes of human fetal and adult dermal fibroblasts in response to extracellular matrix rigidity.
Data on the mechanobiological differences in the transcriptomes of human fetal and adult dermal fibroblasts in response to extracellular matrix rigidity.
复制标题
关于人类胎儿和成人真皮成纤维细胞转录组对细胞外基质刚性反应的机械生物学差异的数据。
DOI：
10.1016/j.dib.2019.104519
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发表时间：
2019
期刊：
影响因子：
1.2
通讯作者：
Parekh,Aron
中科院分区：
文献类型：
--
作者：
Leih,MitchellJ;Ramirez,MarisolA;Jerrell,RachelJ;Parekh,Aron
已知胎儿皮肤在伤口愈合过程中不会形成疤痕组织，而是通过再生进行。胎儿真皮成纤维细胞由于其独特的表型特征而成为这种再生反应的重要驱动力，包括我们最近发现的对细胞外基质（ECM）刚性的减弱收缩反应，通常有助于肌成纤维细胞分化和瘢痕形成。我们在这里提供的数据，这些机械生物学差异胎儿皮肤成纤维细胞也延伸到他们的遗传谱，我们发现353差异表达的基因相比，成人皮肤成纤维细胞。这些数据与题为“胎儿成纤维细胞的机械表型改变阻碍肌成纤维细胞分化”的研究文章相关[1]。
Fetal skin is known to proceed through the wound healing process without the formation of scar tissue but rather via regeneration. Fetal dermal fibroblasts have emerged as a significant driving force in this regenerative response due to their unique phenotypic characteristics including our recent finding of an attenuated contractile response to extracellular matrix (ECM) rigidity that normally contributes to myofibroblast differentiation and scar formation. We provide data here that these mechanobiological differences in fetal dermal fibroblasts also extend to their genetic profile in which we found 353 differentially expressed genes when compared to adult dermal fibroblasts. These data are related to the research article entitled “The altered mechanical phenotype of fetal fibroblasts hinders myofibroblast differentiation” [1].