Lung inflation and longitudinal distribution of pulmonary vascular resistance during hypoxia.
Lung inflation and longitudinal distribution of pulmonary vascular resistance during hypoxia.
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缺氧时肺充气和肺血管阻力的纵向分布。
DOI：
10.1152/jappl.1979.47.3.532
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Linehan
中科院分区：
文献类型：
--
作者：
C. Dawson;D. Grimm;J. Linehan
采用低黏度丸法，研究了肺充气对离体猫肺缺氧时血管阻力纵向分布的影响。缺氧时，经肺压升高会降低血管阻力，但不会改变局部阻力最大的肺活量。这与正常情况相反，在正常情况下，充气会导致阻力在研究的大部分跨肺压力范围内增加，并将最大局部阻力向下游移动。这些结果表明，在缺氧期间，阻力的主要增加是在肺泡外血管，这些血管由肺膨胀引起的扩张降低了升压反应的强度。肺泡血管阻力的增加，在充气时发生，在对照组和缺氧条件下相似，但由于肺泡外血管阻力大得多，在缺氧时占总阻力的比例较小。
Using the low-viscosity bolus method, we examined the influence of lung inflation on the longitudinal distribution of vascular resistance during hypoxia in isolated cat lungs. During hypoxia, increasing transpulmonary pressure decreased vascular resistance but did not change the volume into the lung at which the maximum local resistance was located. This was in contrast to the normoxic situation in which inflation caused an increase in resistance over much of the transpulmonary pressure range studied and moved the maximum local resistance downstream. These results indicate that during hypoxia the major increase in resistance was in extra-alveolar vessels and that distension of these vessels by lung inflation decreased the magnitude of the pressor response. The increase in resistance in alveolar vessels, which occurred on inflation, was similar during control and hypoxic conditions but was a smaller part of the total resistance during hypoxia because of the much larger extra-alveolar vessel resistance.