Immunomodulation in human and experimental arthritis: including vitamin D, helminths and heat-shock proteins
Immunomodulation in human and experimental arthritis: including vitamin D, helminths and heat-shock proteins
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DOI：
10.1177/0961203314527369
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发表时间：
2014-05-01
期刊：
影响因子：
2.6
通讯作者：
Sartori, A.
中科院分区：
文献类型：
--
作者：
Ishikawa, L. L. W.;Shoenfeld, Y.;Sartori, A.
风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病，主要针对关节，影响滑膜、软骨以及骨骼。这种疾病影响世界人口的1%至2%，并与显著的发病率和死亡率增加有关。类风湿性关节炎的实验模型已经允许大量的信息被翻译成相应的人类疾病。这篇综述总结了一些最相关的研究结果，针对免疫调节关节炎。提供了一些选择适当的实验模型的一般指南以及我们对关节炎的经验。
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is mainly directed to the joints, affecting the synovial membrane, the cartilage and also the bone. This disease affects 1% to 2% of the world population and is associated with significant morbidity and increased mortality. RA experimental models have allowed a great deal of information to be translated to the corresponding human disease. This review summarizes some of the most relevant findings targeting immunomodulation in arthritis. Some general guidelines to choose an adequate experimental model and also our experience with arthritis are supplied.