Use of mouse mammary tumour virus (MMTV)/neu transgenic mice to identify genes collaborating with the c-erbB-2 oncogene in mammary tumour development.
Use of mouse mammary tumour virus (MMTV)/neu transgenic mice to identify genes collaborating with the c-erbB-2 oncogene in mammary tumour development.
复制标题
使用小鼠乳腺肿瘤病毒 (MMTV)/neu 转基因小鼠来鉴定与乳腺肿瘤发展中的 c-erbB-2 癌基因协作的基因。
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Diévart
中科院分区：
文献类型：
--
作者：
P. Jolicoeur;L. Bouchard;A. Guimond;M. Ste;Z. Hanna;A. Diévart
小鼠乳腺肿瘤病毒(MMTV)/新转基因小鼠随机发生克隆或寡克隆乳腺肿瘤。这些肿瘤的病理与人类乳腺肿瘤非常相似。此外，这些小鼠肿瘤在肺部转移。我们提出的证据表明，这种人类乳腺肿瘤小鼠模型可以用于鉴定两种不同类型的新基因（激活的癌基因或肿瘤抑制基因），这些基因可能与c-erbB-2/ new转基因癌基因合作。
Mouse mammary tumour virus (MMTV)/neu transgenic mice develop clonal or oligoclonal mammary tumours stochastically. The pathology of these tumours is very similar to that of human breast tumours. Moreover, these mouse tumours metastasize in the lungs. We present evidence that this mouse model of human breast tumours can be instrumental in identifying novel genes of two distinct classes (activated oncogenes or tumour suppressor genes) which may collaborate with the c-erbB-2/neu transgenic oncogene.