Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids.
Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids.
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发表时间：
1993-07
影响因子：
3.6
通讯作者：
N. Mohandas;J. Chasis
中科院分区：
文献类型：
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作者：
N. Mohandas;J. Chasis
膜特性的不寻常组合允许RBC经历广泛的变形而没有细胞碎片，使其能够在循环中的长寿命期间有效地执行其氧气输送功能。这些材料特性是缓慢进化驱动的“工程”的结果，其进化出复合结构，其中由两亲性表面活性剂分子组成的质膜被膜通过双层中的系留位点（跨膜蛋白）锚定到骨架蛋白的网络。爆炸性增长，我们的理解的一级结构的各种红细胞膜蛋白，在各种红细胞表型中的特定突变的定义，和详细的生物物理特性的膜特性的正常和突变的红细胞的发展模型的分子和结构基础的红细胞特性。在这篇综述中，我们试图综合所有这些目前可用的信息，并定义不同的红细胞特性的各种膜组件的贡献。
An unusual combination of membrane properties allows the RBC to undergo extensive deformation without cell fragmentation, enabling it to effectively perform its function of oxygen delivery during its long life span in circulation. These material properties are the consequence of slow evolution-driven "engineering" which evolved a composite structure in which a plasma membrane envelope composed of amphiphilic surfactant molecules is anchored to a network of skeletal proteins through tethering sites (transmembrane proteins) in the bilayer. Explosive growth in our understanding of the primary structure of the various RBC membrane proteins, definition of specific mutations in various RBC phenotypes, and detailed biophysical characterization of membrane properties of normal and mutant RBCs has enabled development of models of the molecular and structural basis for RBC properties. In this review, we have attempted to synthesize all of this currently available information and define the contributions of various membrane components to different RBC properties.