Elevated manganese levels in blood and CNS in human prion disease
Elevated manganese levels in blood and CNS in human prion disease
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DOI：
10.1016/j.mcn.2007.12.008
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Brown, David R.
中科院分区：
文献类型：
--
作者：
Hesketh, Shirley;Sassoon, Judyth;Brown, David R.
Pron病或传染性海绵状脑病是人类和其他哺乳动物的神经退行性疾病。它们是致命的，很难诊断。此前的研究表明，某些普恩病毒疾病会导致血液和大脑中的锰含量升高。在目前的研究中，我们分析了血液和大脑样本。以确定锰的升高是否是克雅氏病的一个特殊特征，克雅氏病是人类最常见的普恩病毒病。对正常人血液中锰的分析表明，锰的浓度随年龄或性别的变化很小。对包括其他神经退行性疾病在内的其他疾病的分析表明，只有CJD表现出锰和铜的升高。其他表现出锰含量升高的疾病包括血脑屏障障碍和血色素沉着症。然而，CJD很容易与这些疾病区分开来。这意味着Pron病的血锰升高是该病的高度特异性特征。(C)2007 Elsevier Inc.保留所有权利。
Prion disease or transmissible spongiform encephalopathies are neurodegenerative disorders of humans and other mammals. They are fatal and difficult to diagnose. Previous studies have suggested that some prion diseases cause elevation of manganese in the blood and brain. In the current study we analysed blood and brain samples. from humans to determine whether elevation in manganese is a specific characteristic of Creutzfeldt-Jakob disease, the most common form of human prion disease. Analysis of manganese in the blood Of normal humans showed that concentrations vary little with age or sex. Analysis of other diseases, including other neurodegenerative disease showed that only CJD showed an elevation in manganese and copper. Other diseases that showed elevated manganese included blood-brain barrier disorders and haemochromatosis. However, CJD could be easily distinguished from these diseases. This implies that increased blood manganese in prion disease is a highly specific characteristic Of the disease. (c) 2007 Elsevier Inc. All rights reserved.