Antihypertensive and neuroprotective effects of astaxanthin in experimental animals
Antihypertensive and neuroprotective effects of astaxanthin in experimental animals
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DOI：
10.1248/bpb.28.47
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Watanabe, H
中科院分区：
文献类型：
--
作者：
Hussein, G;Nakamura, M;Watanabe, H
虾青素是一种天然的抗氧化剂类胡萝卜素，存在于各种生物体中。我们首次研究了虾青素（ASX-O）对自发性高血压大鼠（SHR）的降压作用。口服ASX-O 14 d可显著降低SHR的动脉血压（BP），但对正常血压的Wistar京都（WKY）品系无明显影响。在易卒中SHR（SHR-SP）中长期施用ASX-O（50 mg/kg）5周诱导BP显著降低。为探讨ASX-O的作用机制，本实验观察了N-G-硝基-L-精氨酸甲酯（L-NAME）对PGF（2 α）诱导的大鼠离体主动脉收缩的影响。ASX-O（1至10 μ m）诱导一氧化氮（NO）介导的血管舒张。结果表明，ASX-O的降压作用可能是由于NO相关的机制。ASX-O在缺血小鼠中也显示出显著的神经保护作用，可能是由于其抗氧化潜力。ASX-O预处理可显著缩短Morris水迷宫实验中小鼠逃避平台的潜伏期。总之，这些结果表明，虾青素可以发挥有益的作用，防止高血压和中风，并在改善血管性痴呆的记忆。
Astaxanthin is a natural antioxidant carotenoid that occurs in a wide variety of living organisms. We investigated, for the first time, antihypertensive effects of astaxanthin (ASX-O) in spontaneously hypertensive rats (SHR). Oral administration of ASX-O for 14 d induced a significant reduction in the arterial blood pressure (BP) in SHR but not in normotensive Wistar Kyoto (WKY) strain. The long-term administration of ASX-O (50 mg/kg) for 5 weeks in stroke prone SHR (SHR-SP) induced a significant reduction in the BP. It also delayed the incidence of stroke in the SHR-SP. To investigate the action mechanism of ASX-O, the effects on PGF(2alpha)-induced contractions of rat aorta treated with N-G-nitro-l-arginine methyl ester (L-NAME) were studied in vitro. ASX-O (1 to 10 mum) induced vasorelaxation mediated by nitric oxide (NO). The results suggest that the antihypertensive effect of ASX-O may be due to a NO-related mechanism. ASX-O also showed significant neuroprotective effects in ischemic mice, presumably due to its antioxidant potential. Pretreatment of the mice with ASX-O significantly shortened the latency of escaping onto the platform in the Morris water maze learning performance test. In conclusion, these results indicate that astaxanthin can exert beneficial effects in protection against hypertension and stroke and in improving memory in vascular dementia.