Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates
Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates
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N-酰基修饰 Tn 类似物作为抗癌疫苗候选物的合成和免疫学评价
DOI：
10.1016/j.bmc.2016.01.015
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发表时间：
2016
影响因子：
3.5
通讯作者：
Ye Xin-Shan
中科院分区：
文献类型：
--
作者：
Song Chengcheng;Sun Shuang;Huo Chang-Xin;Li Qin;Zheng Xiu-Jing;Tai Guihua;Zhou Yifa;Ye Xin-Shan
Tumor-associated carbohydrate antigens (TACAs), which are aberrantly expressed on the surface of tumor cells, are important targets for anticancer vaccine development. Herein, severalN-acyl modified Tn analogues were synthesized and conjugated with carrier protein CRM197. The immunological results of these glycoconjugates indicated that6–CRM197 elicited higher titers of antibodies which cross-reacted with native Tn antigen than the unmodified2–CRM197 did. The IFN-γ-producing frequency of lymphocytes in mice treated with6–CRM197 was obviously increased, compared to that of mice vaccinated with2–CRM197 (p= 0.016), which was typically associated with the Th1 response. Moreover, the elicited antisera against antigen6–CRM197 reacted strongly with the Tn-positive tumor cells, implying the potential of this glycoconjugate as an anticancer vaccine.
