The burden of fatigue and quality of life in myeloproliferative disorders (MPDs) - An international internet-based survey of 1179 MPD patients
The burden of fatigue and quality of life in myeloproliferative disorders (MPDs) - An international internet-based survey of 1179 MPD patients
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DOI：
10.1002/cncr.22365
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发表时间：
2007-01-01
期刊：
影响因子：
6.2
通讯作者：
Tefferi, Ayalew
中科院分区：
文献类型：
--
作者：
Mesa, Ruben A.;Niblack, Joyce;Tefferi, Ayalew
背景。关于骨髓增生性疾病（MPD）患者的疲劳负担和其他全身症状的客观数据很少。方法。作者在对 1179 名 MPD 患者（中位年龄 56 岁；41.4% 男性）进行的基于互联网的症状调查中使用了经过验证的疲劳和体力活动评估工具。 结果。自我报告疲劳的频率为80.7%，明显高于瘙痒（52.2%）、盗汗（49.2%）、骨痛（43.9%）、发热（13.7%）和体重减轻（13.1%）。在大多数患者中，这些症状限制了对社会功能和身体活动的参与。此外，34.5% 的患者需要日常生活活动方面的帮助，11.2% 的患者报告与 MPD 相关的医疗残疾。正如预期的那样，骨髓纤维化、贫血、脾肿大或与晚期疾病相关的其他特征的存在有利于更高程度的疲劳。然而，疲劳仍然是真性红细胞增多症（84.9%）和原发性血小板增多症（72.4%）的主要主诉；这些数字显着高于已发表的对照数据 (P < .0001)。结论。目前的研究确定疲劳是 MPD 患者生活质量差的主要原因，提供了全身症状的基线信息，并强调了将生活质量评估纳入临床试验的必要性。癌症 2007 年；109：68-76。 (c) 2006 年美国癌症协会。
BACKGROUND. Few objective data exist on the burden of fatigue and other constitutional symptoms in patients with myeloproliferative disorders (MPD).METHODS. The authors used validated instruments of fatigue and physical activity assessment during an Internet-based symptom survey of 1179 MPD patients (median age, 56 years; 41.4% men).RESULTS. The frequency of self-reporting was 80.7% for fatigue, which was substantially higher than that of pruritus (52.2%), night sweats (49.2%), bone pain (43.9%), fever (13.7%), and weight loss (13.1%). In the majority of patients, these symptoms restricted participation in both social functions and physical activity. In addition, 34.5% of patients needed assistance with activities of daily living, and 11.2% reported MPD-associated medical disability. As expected, the presence of myelofibrosis, anemia, splenomegaly, or other features associated with advanced disease favored a higher degree of fatigue. However, fatigue remained the major complaint also in polycythemia vera (84.9%) and essential thrombocythemia (72.4%); these figures were significantly higher than those of published controls (P < .0001).CONCLUSIONS. The current study identifies fatigue as the major contributor to poor quality of life in MPD, provides baseline information on constitutional symptoms, and underscores the need for the incorporation of quality of life assessment in clinical trials. Cancer 2007;109:68-76. (c) 2006 American Cancer Society.