Nuclear magnetic resonance imaging of a fibrosarcoma tumor implanted in the rat.
Nuclear magnetic resonance imaging of a fibrosarcoma tumor implanted in the rat.
复制标题
植入大鼠体内的纤维肉瘤肿瘤的核磁共振成像。
DOI：
10.1148/radiology.148.1.6856831
复制
发表时间：
1983
期刊：
影响因子：
19.7
通讯作者：
Watts,JC
中科院分区：
文献类型：
--
作者：
MoonJr,KL;Davis,PL;Kaufman,L;Crooks,LE;Sheldon,PE;Miller,T;Brito,AC;Watts,JC
将纤维肉瘤肿瘤细胞植入25只大鼠的后腿，并从植入后第一到第六周进行研究。核磁共振成像检测到了所有肿瘤，并且在五只对照大鼠中没有产生任何假阳性。肿瘤的T1弛豫值与肌肉的T1弛豫值重叠，T2弛豫值与脂肪的T2弛豫值重叠，但两个值的组合允许区分三种组织中的每一种，而没有重叠。肿瘤和肌肉之间弛豫时间的差异可以根据含水量来解释，肿瘤中的含水量高出约14%。这项研究证实了以前的研究数据表明，核磁共振成像是一种高度敏感的方式，但T1和T2值是不是具体的个人病理条件。
Fibrosarcoma tumor cells were implanted in the hind legs of 25 rats and studied from the first to the sixth week postimplantation. Nuclear magnetic resonance imaging detected all tumors and did not yield any false-positives in five control rats. The T1 relaxation values of tumors overlapped those of muscle, and the T2 values overlapped those of fat, but the combination of the two values allowed discrimination of each of the three tissues with no overlap. The difference in relaxation time between tumor and muscle could be accounted for on the basis of water content, which was approximately 14% higher in the tumors. This study confirms data from previous studies suggesting that nuclear magnetic resonance imaging is a highly sensitive modality, but that T1 and T2 values are not specific for individual pathologic conditions.