Roles of HIV-1 capsid in viral replication and immune evasion
Roles of HIV-1 capsid in viral replication and immune evasion
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DOI：
10.1016/j.virusres.2014.07.010
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发表时间：
2014-11-26
期刊：
影响因子：
5
通讯作者：
Valiente-Echeverria, Fernando
中科院分区：
文献类型：
--
作者：
Le Sage, Valerie;Mouland, Andrew J.;Valiente-Echeverria, Fernando
人类免疫缺陷病毒1型(HIV-1)衣壳蛋白(CA)的主要作用是包裹和保护病毒RNA基因组。越来越明显的是，HIV-1CA是一种多功能蛋白质，在感染早期就起作用，协调前整合复合体的去壳、逆转录、核输入和双链病毒DNA整合到宿主基因组中。此外，最近的大量研究表明，CA在HIV-1免疫逃避中起着至关重要的作用。在这里，我们总结了目前关于HIV-1CA及其与宿主细胞相互作用促进感染的知识。事实上，CA参与了许多不同的蛋白质-蛋白质与宿主的相互作用，这使得它成为开发新的有效抗病毒药物的有趣靶点。(C)2014爱思唯尔B.V.保留所有权利。
The primary roles of the human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein are to encapsidate and protect the viral RNA genome. It is becoming increasing apparent that HIV-1 CA is a multifunctional protein that acts early during infection to coordinate uncoating, reverse transcription, nuclear import of the pre-integration complex and integration of double stranded viral DNA into the host genome. Additionally, numerous recent studies indicate that CA is playing a crucial function in HIV-1 immune evasion. Here we summarize the current knowledge on HIV-1 CA and its interactions with the host cell to promote infection. The fact that CA engages in a number of different protein-protein interactions with the host makes it an interesting target for the development of new potent antiviral agents. (C) 2014 Elsevier B.V. All rights reserved.