Endocrine and cardiovascular influences of converting enzyme inhibition with SQ 14225 in hypertensive patients in the supine position and during head-up tilt before and after sodium depletion.
Endocrine and cardiovascular influences of converting enzyme inhibition with SQ 14225 in hypertensive patients in the supine position and during head-up tilt before and after sodium depletion.
复制标题
SQ 14225 抑制高血压患者仰卧位和钠消耗前后抬头倾斜期间的内分泌和心血管影响。
DOI：
10.1210/jcem-50-4-748
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Laragh
中科院分区：
文献类型：
--
作者：
A. Morganti;T. Pickering;J. Lopez;J. Laragh
在这项研究中，我们研究了口服活性血管紧张素转换酶抑制剂SQ 14225（Captopril）对血压，心率，血浆去甲肾上腺素和肾上腺素，PRA，醛固酮，皮质醇和血清钾的影响，在15个钠充足的高血压患者在仰卧位和30分钟的头高位倾斜;在3例患者相同的调查后，钠剥夺重复。在正常钠摄入量下，SQ 14225短期治疗（平均剂量为480 ± 60 mg/天）可使平均仰卧位血压降低19 ± 3 mm Hg（P <0.001）;这种变化与PRA增加12.2 ± 3.2 ng/ml·h相关（P <0.001），血浆醛固酮下降4.8 ± 1.9 ng/100 ml（P <0.01），同时血清钾升高0.26 ± 0.1 meq/L（P/0.05）。仰卧位心率和血浆去甲肾上腺素、肾上腺素和皮质醇无变化。虽然在控制倾斜研究中，所有患者的平均血压均无变化，但在转换酶抑制期间（C...
In this study we examined the effects of the orally active angiotensin-converting enzyme inhibitor SQ 14225 (Captopril) on blood pressure, heart rate, plasma norepinephrine and epinephrine, PRA, aldosterone, cortisol, and serum potassium in 15 sodium-repleted hypertensive patients in the supine position and during 30 min of head-up tilt; in 3 patients the same investigations were repeated after sodium deprivation. On normal sodium intake, a short term treatment with SQ 14225, at average doses of 480 ± 60 mg⁄day, reduced mean supine blood pressure by 19 ± 3 mm Hg (P < 0.001); this change was associated with an increase in PRA of 12.2 ± 3.2 ng⁄ml.h (P < 0.001), a fall in plasma aldosterone of 4.8 ± 1.9 ng⁄100 ml (P < 0.01), and a concurrent rise in serum potassium of 0.26 ±0.1 meq⁄liter (P ⁄ 0.05). Supine heart rate and plasma norepinephrine, epinephrine and cortisol were unchanged. Although in control tilt studies the mean blood pressure was unchanged in all patients, during converting enzyme inhibition (C...