Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study
Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study
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DOI：
10.1007/s12603-022-1763-2
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发表时间：
2022-03-22
影响因子：
5.8
通讯作者：
Amaro-Gahete, F. J.
中科院分区：
文献类型：
--
作者：
De-la-O, A.;Jurado-Fasoli, Lucas;Amaro-Gahete, F. J.
背景衰老过程可能受到能量摄入和饮食中不同常量营养素的影响。a-Klotho基因的可溶形式（称为S-Klotho）被广泛认为是一种强大的抗衰老生物标志物。目的分析中年久坐人群能量、膳食能量密度和大量营养素摄入量与血浆S-Klotho水平的关系。方法共有72名（52.8%女性）中年久坐成年人（53.7 +/- 5.2岁）参加了这项研究。能量和常量营养素摄入（即脂肪，碳水化合物和蛋白质）使用三个非连续的24小时回忆进行评估。使用固相夹心酶联免疫吸附试验测定乙二胺四乙酸（EDTA）血浆中的S-Klotho血浆水平。结果男性的能量、膳食能量密度或常量营养素摄入量与血浆S-Klotho水平之间无相关性（均P >= 0.1）。我们发现，女性的能量、蛋白质和碳水化合物摄入量与S-Klotho血浆水平呈负相关（均P
Background The ageing process can be influenced by energy intake and different macronutrients within the diet. The soluble form of the a-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker. Objective To analyze the association of energy, dietary energy density and macronutrient intake with S-Klotho plasma levels in middle-aged sedentary adults. Methods A total of 72 (52.8% women) middle-aged sedentary adults (53.7 +/- 5.2 years old) participated in the study. Energy and macronutrients intake (i.e. fat, carbohydrate and protein) were assessed using three non-consecutive 24-h recalls. S-Klotho plasma levels were measured in the Ethylenediaminetetraacetic acid (EDTA) plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Results No association was observed between energy, dietary energy density or macronutrient intake and S-Klotho plasma levels in men (all P >= 0.1). We found an inverse association between energy, protein and carbohydrate intake with S-Klotho plasma levels in women (all P