Associations between female birth sex and risk of chronic kidney disease development among people with HIV in the USA: A longitudinal, multicentre, cohort study.
Associations between female birth sex and risk of chronic kidney disease development among people with HIV in the USA: A longitudinal, multicentre, cohort study.
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DOI：
10.1016/j.eclinm.2022.101653
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发表时间：
2022-11
影响因子：
15.1
通讯作者：
Locke, Jayme E.
中科院分区：
文献类型：
--
作者：
Shelton, Brittany A.;Sawinski, Deirdre;MacLennan, Paul A.;Lee, Wonjun;Wyatt, Christina;Nadkarni, Girish;Fatima, Huma;Mehta, Shikha;Crane, Heidi M.;Porrett, Paige;Julian, Bruce;Moore, Richard D.;Christopoulos, Katerina;Jacobson, Jeffrey M.;Muller, Elmi;Eron, Joseph J.;Saag, Michael;Peter, Inga;Locke, Jayme E.
妇女在新的艾滋病毒诊断中占有相当大的比例，黑人妇女占妇女新诊断病例的58%。由于艾滋病毒感染还会增加患慢性肾脏疾病(CKD)的风险，了解感染艾滋病毒的妇女(WWH)，特别是黑人妇女患CKD的风险至关重要。在这项对CFAR综合临床系统网络(CNICS)登记的艾滋病毒携带者(PWH)的纵向队列研究中，从1996年1月1日到2019年11月1日，由全美八个学术医疗中心组成的多中心研究中，如果成年PWH有≤2血清肌酐测量，在登记前患有慢性肾脏病，或者被确定为双性或变性人，则排除成年PWH，留下33,998名PWH。结果是慢性肾脏病的发展，定义为估计的肾小球滤过率(EGFR)和使用CKD-EPI方程计算的60毫升/分钟/1·73m2，对于≥90天，没有介入性较高的值。调整人口学和临床特征，WWH患CKD的可能性比男性高61%(调整后的危险比[AHR]：1·61，95%CI：1·46-1·78，p<；0·001)。在进一步调整APOL1风险变量(AHR女性：1·92，95%CI：1·63-2·26，P<；0·001)和药物滥用(AHR女性：1·70，95%CI：1·54-1·87，P<；0·001)后，这种差异仍然存在。WWH患慢性肾脏病的风险增加。考虑到终末期肾病患者之间的护理差异，努力让WWH参与肾脏病护理以改善慢性病管理是至关重要的。美国国立卫生研究院。
Women represent a meaningful proportion of new HIV diagnoses, with Black women comprising 58% of new diagnoses among women. As HIV infection also increases risk of chronic kidney disease (CKD), understanding CKD risk among women with HIV (WWH), particularly Black women, is critical. In this longitudinal cohort study of people with HIV (PWH) enrolled in CFAR Network of Integrated Clinical Systems (CNICS), a multicentre study comprised of eight academic medical centres across the United States from Jan 01, 1996 and Nov 01, 2019, adult PWH were excluded if they had ≤2 serum creatinine measurements, developed CKD prior to enrollment, or identified as intersex or transgendered, leaving a final cohort of 33,998 PWH. The outcome was CKD development, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1·73 m2 calculated using the CKD-EPI equation, for ≥90 days with no intervening higher values. Adjusting for demographic and clinical characteristics, WWH were 61% more likely to develop CKD than men (adjusted hazard ratio [aHR]: 1·61, 95% CI: 1·46-1·78, p<0·001). This difference persisted after further adjustment for APOL1 risk variants (aHR female sex: 1·92, 95% CI: 1·63-2·26, p<0·001) and substance abuse (aHR female sex: 1·70, 95% CI: 1·54-1·87, p<0·001). WWH experienced increased risk of CKD. Given disparities in care among patients with end-stage kidney disease, efforts to engage WWH in nephrology care to improve chronic disease management are critical. US National Institutes of Health.
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影响因子：
6
作者：
Earnshaw VA;Bogart LM;Laurenceau JP;Chan BT;Maughan-Brown BG;Dietrich JJ;Courtney I;Tshabalala G;Orrell C;Gray GE;Bangsberg DR;Katz IT
通讯作者：
Katz IT
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
11.8
作者：
Althoff, Keri N.;McGinnis, Kathleen A.;Justice, Amy C.
通讯作者：
Justice, Amy C.
DOI：
10.1080/09540121.2013.844759
发表时间：
2014-05-04
影响因子：
1.7
作者：
Boehme, Amelia K.;Davies, Susan L.;Kempf, Mirjam-Colette
通讯作者：
Kempf, Mirjam-Colette
影响因子：
4.9
作者：
Buchberg, Meredith K.;Fletcher, Faith E.;Bell, Tanvir K.
通讯作者：
Bell, Tanvir K.