Early molecular-recognition events in the synthesis and export of group 2 capsular polysaccharides.

Early molecular-recognition events in the synthesis and export of group 2 capsular polysaccharides.
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DOI:
10.1099/mic.0.023564-0
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发表时间:
2009-01
期刊:
Microbiology (Reading, England)
影响因子:
--
通讯作者:
Steenbergen SM
Steenbergen SM
中科院分区:
其他
文献类型:
--
作者:
Vimr ER;Steenbergen SM

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几乎所有革兰氏阴性细菌的外膜 (OM) 由磷脂、脂多糖、蛋白质和荚膜或多糖组成,它们共同介导细胞与不同环境的相互作用。大多数 OM 成分是在细胞内或内膜 (IM) 合成的,因此需要输出机制。这篇小综述重点关注了解一种荚膜多糖(第 2 类)的合成如何与位于 IM 中并跨越周质空间的输出装置耦合,从而提供通往细胞表面的运输通道的最新进展。尽管这些研究的模型系统是医学上重要的肠外病原体大肠杆菌 K1 及其聚唾液酸胶囊,但这些结论对于许多不同细菌种类合成的其他第 2 族和类 2 多糖来说是通用的。
The outer membrane (OM) of almost all Gram-negative bacteria is composed of phospholipids, lipopolysaccharide, proteins and capsular or loosely adherent polysaccharides that together mediate cellular interactions with diverse environments. Most OM components are synthesized intracellularly or at the inner membrane (IM) and thus require an export mechanism. This mini-review focuses on recent progress in understanding how synthesis of one kind of capsular polysaccharide (group 2) is coupled to the export apparatus located in the IM and spanning the periplasmic space, thus providing a transport channel to the cell surface. Although the model system for these investigations is the medically important extraintestinal pathogen Escherichia coli K1 and its polysialic acid capsule, the conclusions are general for other group 2 and group 2-like polysaccharides synthesized by many different bacterial species.
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