The Titrated Monetary Incentive Delay Task: Sensitivity, convergent and divergent validity, and neural correlates in an RDoC sample
The Titrated Monetary Incentive Delay Task: Sensitivity, convergent and divergent validity, and neural correlates in an RDoC sample
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DOI：
10.1080/13803395.2019.1585519
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发表时间：
2019-03-28
影响因子：
2.2
通讯作者：
Langenecker, Scott A.
中科院分区：
文献类型：
--
作者：
DelDonno, Sophie R.;Karstens, Aimee James;Langenecker, Scott A.
介绍：神经心理学测试旨在通过性能测量来分析大脑功能。与视觉和运动皮层功能相对应的许多测试已经被验证。探索奖励回路（包括腹侧纹状体（VS））的测试可能有助于评估奖励或VS功能受到干扰的许多神经和精神疾病。本研究旨在探讨收敛和发散的有效性，我们的修改，滴定版本的货币奖励延迟任务，使其在未来可能会成为一个有效的神经心理学测试的奖励功能。方法：研究对象为132名有心境障碍（HMD）病史的人和43名健康对照者，年龄18-30岁。除了标准的神经心理电池和症状测量外，参与者还在功能性磁共振成像（fMRI）期间完成了货币激励延迟任务（T-MIDT）的修改版本，其中涉及多阶段滴定程序，以根据每个参与者的心理速度逐步增加或减少响应窗口时间，并优化个人表现。结果如下：在滴定后的各组中，T-MIDT的表现与处理速度、注意力和空间工作记忆的测量结果不同，但与抑制控制无关。HMD组的表现与滴定前后的执行功能测量差异相关。奖励电路（例如，皮层下、岛叶、内侧前额叶）在奖赏预期期间被激活。结论：目前的研究结果提供了初步的证据表明，T-MIDT措施的构造不同于许多执行功能，个性化滴定的任务参数是至关重要的，在解析奖励执行功能。T-MIDT与缓解型抑郁症或双相情感障碍患者的残余情绪症状相关，这意味着行为或大脑激活组差异仅在疾病的活动状态下观察到。
Introduction: Neuropsychological tests are designed to assay brain function via performance measurements. Many tests corresponding to visual and motor cortex function have been validated. Tests probing reward circuitry, including the ventral striatum (VS), could benefit assessment of numerous neurological and psychiatric disorders in which reward or VS function is disturbed. The present study sought to examine convergent and divergent validity of our modified, titrated version of the Monetary Incentive Delay Task, such that it may in the future stand as a validated neuropsychological test for reward function. Method: Participants were 132 individuals with a history of mood disturbance (HMD) and 43 healthy comparisons, ages 18-30 years. In addition to a standard neuropsychological battery and symptom measures, participants completed a modified version of the Monetary Incentive Delay Task (T-MIDT) during functional magnetic resonance imaging (fMRI), which involved a multistage titration procedure to incrementally increase or decrease the response window time per each participant's psychomotor speed and optimize individual performance. Results: Across groups after titration, performance on the T-MIDT diverged from measures of processing speed, attention, and spatial working memory, but not inhibitory control. Performance in the HMD group was differentially correlated with executive function measures before and after titration. The reward circuit (e.g., subcortical, insular, medial prefrontal) was activated during reward anticipation. Conclusion: The present findings provide preliminary evidence that the T-MIDT measures a construct distinct from many executive functions and that individualized titration of the task parameters is critical in parsing reward from executive function. The T-MIDT correlated with residual mood symptoms in individuals with remitted depression or bipolar disorder, implying that behavioral or brain activation group differences are only to be observed in the active state of illness.