Incidence Rate of Herpes Zoster Ophthalmicus A Retrospective Cohort Study from 1994 through 2018
Incidence Rate of Herpes Zoster Ophthalmicus A Retrospective Cohort Study from 1994 through 2018
复制标题
DOI：
10.1016/j.ophtha.2019.10.001
复制
发表时间：
2020-03-01
期刊：
影响因子：
13.7
通讯作者：
Acharya, Nisha R.
中科院分区：
文献类型：
--
作者：
Kong, Christina L.;Thompson, Ryan R.;Acharya, Nisha R.
目的：分析1994年至2018年带状疱疹眼（HZO）的发病率（IR）以及年龄、性别、种族和地区的差异。设计：回顾性、观察性队列研究。参与者：从1994年1月1日至2018年12月31日，患有新的国际疾病分类第九版或第十版带状疱疹（HZ）和HZO代码的患者，OptumLabs数据仓库（OptumLabs，剑桥，MA）。方法：OptumLabs数据仓库，一种具有去识别的行政索赔和电子健康记录数据的纵向真实世界数据资产，用于识别在数据库中连续登记365天或更长时间的登记者。无HZ或HZO病史和HZ和HZO新代码的患者计为事件病例。HZO的IR按年份、10岁年龄组、性别、种族和地区计算。主要结果指标：1994年至2018年按10岁年龄组和性别计算的IR差异。结果：从1994年至2018年，报告了633 474例HZ，其中49 745例（7.9%）患有HZO。从1994年到2018年，HZO的发病率估计每年每10万人年增加1.1例（95%置信区间[CI]，1.0-1.3; P < 0.001）。估计的相对增长率为每年3.6%（95% CI，3.0%-4.1%）。HZO IR在10年内增加，直到2007年，然后在21岁以下和60岁以上的个体中开始下降，在21至30岁的个体中稳定，在31至60岁的个体中增加较慢。与女性相比，男性HZO发病率比（IRR）为0.74。与白色患者相比，亚洲人、黑人患者和西班牙裔患者的IRR分别为0.70、0.75和0.64.Conclusions：从1994年到2018年，美国HZO的发病率每年增加3.6%。自2008年以来，21岁以下和60岁以上人群的HZO发病率下降，而中年人的发病率上升速度较低。鉴于这种情况持续增加，应加大力度为50岁及以上符合条件的成年人接种疫苗。需要对早期疫苗接种进行更多的研究。(C)2019年美国眼科学会
Purpose: To analyze the incidence rate (IR) of herpes zoster ophthalmicus (HZO) and differences by age, gender, race, and region from 1994 through 2018.Design: Retrospective, observational cohort study.Participants: Patients with a new International Classification of Diseases, Ninth or Tenth Edition, codes for herpes zoster (HZ) and HZO from January 1, 1994, through December 31, 2018, in the OptumLabs Data Warehouse (OptumLabs, Cambridge, MA).Methods: OptumLabs Data Warehouse, a longitudinal, real-world data asset with de-identified administrative claims and electronic health record data, was used to identify enrollees with continuous enrollment in the database for 365 days or more. Patients with no history of HZ or HZO and a new code for HZ and HZO were counted as incident cases. The IR of HZO was calculated by year, 10-year age groups, gender, race, and region.Main Outcome Measures: Differences in IR from 1994 through 2018 by 10-year age groups and gender.Results: From 1994 through 2018, 633 474 cases of HZ were reported, with 49 745 (7.9%) having HZO. The incidence of HZO increased from 1994 through 2018 by an estimated 1.1 cases per 100 000 person-years annually (95% confidence interval [CI], 1.0-1.3; P < 0.001). The estimated relative increase was 3.6% annually (95% CI, 3.0%-4.1 %). HZO IR increased in all ages over 10 years until 2007, then began declining in individuals younger than 21 and older than 60, stabilizing in individuals 21 to 30 years old, and increasing more slowly among individuals 31 to 60 years old. Men showed an HZO incidence rate ratio (IRR) of 0.74 compared with women. Compared with white patients, the IRRs were 0.70, 0.75, and 0.64 for Asians, black patients, and Hispanics, respectively.Conclusions: The incidence of HZO has increased 3.6% per year from 1994 to 2018 in the United States. Since 2008, HZO incidence declined in individuals younger than 21 years and older than 60 years while increasing at a lower rate in middle-aged adults. Given the continued increase, greater efforts should be made to vaccinate eligible adults 50 years of age and older. More research on earlier vaccination is warranted. (C) 2019 by the American Academy of Ophthalmology