UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer
UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer
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DOI：
10.1080/07357907.2020.1747483
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发表时间：
2020-04-15
影响因子：
2.4
通讯作者：
Sato, Mitsuo
中科院分区：
文献类型：
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作者：
Goto, Daiki;Komeda, Kazuki;Sato, Mitsuo
我们评估了UHRF 1作为肺癌生物标志物的价值，UHRF 1是一种甲基化调节因子。UHRF 1在肺腺癌（AD）和鳞状细胞癌（SQ）中表达水平较高;然而，荟萃分析显示，UHRF 1表达与AD患者的生存率降低相关，但与SQ患者无关。UHRF 1基因敲减可使肺癌细胞生长受到抑制，部分细胞系发生G1期阻滞。这些结果表明，UHRF 1可以作为AD和SQ的诊断标志物以及肺癌AD的预后标志物。
We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.