Dust and airborne exposure to allergens derived from cockroach (Blattella germanica) in low-cost public housing in Strasbourg (France)
Dust and airborne exposure to allergens derived from cockroach (Blattella germanica) in low-cost public housing in Strasbourg (France)
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DOI：
10.1016/s0091-6749(97)70307-5
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发表时间：
1997-01-01
影响因子：
14.2
通讯作者：
Pauli, G
中科院分区：
文献类型：
--
作者：
deBlay, F;Sanchez, J;Pauli, G
背景资料：尽管在美国和亚洲已经观察到蟑螂过敏（CR）和哮喘之间的强关联，但关于欧洲暴露于CR过敏原的程度的数据很少。目的：测定斯特拉斯堡公寓灰尘样品中CR过敏原的水平，并确定空气中CR过敏原的浓度和大小。根据CR侵扰的视觉证据，选择了一个公共住宅区的九套公寓。用单克隆抗体免疫分析法测定厨房和床垫灰尘中CR变应原（Bla g 1和Bla g 2）的水平。在未受干扰的条件下，在人工干扰期间和正常的家庭活动期间，通过使用撞击器和平行的玻璃纤维过滤器在2至20 L/min的流速下在厨房中对空气采样3至8小时。在人工干扰之前，期间和之后，在一个公寓的卧室中同时测量空气CR和螨过敏原。在9间公寓的厨房灰尘中发现了高水平的Bla g 1和Bla g 2（几何平均值分别为3919 U/gm [范围530至14306 U/gm]和497 U/gm [范围73至1946 U/gm]）。在不受干扰的条件下，空气中的CR过敏原在任何公寓都检测不到。在强烈的人工干扰期间，在7个公寓前的ab样本中可检测到Bin g I和Bla g 2（几何平均值分别为4.5 U/m（3）[范围0.7至17.2 U/m（3）]和1.0 U/m（3）[范围0.4至3.4 U/m（3）]）。这两种过敏原主要收集在第一阶段的撞击器和76%至80%的空气中的过敏原与颗粒直径大于10 μ m。该水平显著高于在撞击器的第二或第三阶段收集的水平（p < 0.001）。螨和CR过敏原的水平的比较表明，这些过敏原的空气传播特性是相似的，也就是说，只能在干扰和检测不到30分钟后disturbance.Conclusion：CR过敏原在低成本的公共住房在斯特拉斯堡的水平可以高达OL高于在美国的城镇测量的水平。CR过敏原在干扰期间通过空气传播，主要与直径大于10 μ m的颗粒有关。应评估居住在欧洲城市地区、房屋易受CR侵扰的哮喘患者对CR过敏原的致敏性和暴露情况。
Background: Although a strong association between allergy to cockroach (CR) and asthma has been observed in the United States and Asia, there are little data about the extent of exposure to CR allergen in Europe.Objective: To deter-mine the levels of CR allergens in dust samples from apartments in strasbourg and to determine the concentration and size of CR allergens in the air.Methods: Nine apartments in a public housing complex were chosen on the basis of visual evidence of CR infestation. Levels of CR allergens (Bla g 1 and Bla g 2) in kitchen and mattress dust samples were measured by immunoassay with the use of monoclonal antibodies. Air was sampled for 3 to 8 hours in the kitchen under undisturbed conditions, during artificial disturbance and during normal domestic activity by using an impinger and a parallel glass fiber filter and at flow rates of 2 to 20 L/min. Airborne CR and mite allergens were measured concurrently in the bedroom of one apartment before, during, and after artificial disturbance.Results: High levels of Bla g 1 and Bla g 2 were found in kitchen dust from the nine apartments (geometric means of 3919 U/gm [range 530 to 14306 U/gm] and 497 U/gm [range 73 to 1946 U/gm], respectively). Under undisturbed conditions, airborne CR allergens were not detectable in any of the apartments. During vigorous artificial disturbance, Bin g I and Bla g 2 were detectable in ab samples front seven apartments (geometric means of 4.5 U/m(3) [range 0.7 to 17.2 U/m(3)] and 1.0 U/m(3) [range 0.4 to 3.4 U/m(3)], respectively). Both allergens were predominantly collected on the first stage of the impinger; and 76% to 80% of the airborne allergen was associated with particles greater than 10 mu m in diameter. The levels were significantly higher than those collected on the second or third stages of the impinger (p < 0.001). A comparison of the levels of mite and CR allergens showed that the airborne properties of these allergens were similar; that is, measurable only during disturbance and not detectable 30 minutes after disturbance.Conclusion: Levels of CR allergen in low-cost public housing in Strasbourg can be as high as ol higher than the levels measured in towns in the United States. CR allergens become airborne during disturbance and are primarily associated with particles greater than 10 mu m in diameter. Patients with asthma living in urban areas of Europe in housing prone to CR infestation should be evaluated for sensitization and exposure to CR allergens.