Genotyping of 353 Staphylococcus aureus Bloodstream Isolates Collected between 2004 and 2009 at a Norwegian University Hospital and Potential Associations with Clinical Parameters
Genotyping of 353 Staphylococcus aureus Bloodstream Isolates Collected between 2004 and 2009 at a Norwegian University Hospital and Potential Associations with Clinical Parameters
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DOI：
10.1128/jcm.01352-12
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发表时间：
2012-09-01
影响因子：
9.4
通讯作者：
Eskesen, Arne N.
中科院分区：
文献类型：
--
作者：
Aamot, Hege Vangstein;Blomfeldt, Anita;Eskesen, Arne N.
我们分析了2004年至2009年353株金黄色葡萄球菌血流分离株，以确定优势基因型，随时间的变化，以及基因型，表型和临床参数之间的关联。分离株进行基因分型的温泉型和潘顿-瓦伦丁杀白细胞素和中毒性休克综合征毒素1编码基因的存在。检测到高水平的遗传多样性。除三个菌株外，所有菌株均对甲氧西林敏感。有趣的是，温泉克隆复合体021与较高的全因医院死亡率呈弱相关性。
We analyzed 353 Staphylococcus aureus bloodstream isolates from 2004 to 2009 to identify dominant genotypes, changes over time, and associations between genotype, phenotype, and clinical parameters. The isolates were genotyped with regard to spa type and presence of Panton-Valentine leukocidin and toxic shock syndrome toxin 1-encoding genes. A high level of genetic diversity was detected. All but three isolates were methicillin sensitive. Interestingly, spa clonal complex 021 showed a weak association with higher all-cause hospital mortality.