Cohort Profile: NICHD Fetal Growth Studies-Singletons and Twins
Cohort Profile: NICHD Fetal Growth Studies-Singletons and Twins
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DOI：
10.1093/ije/dyx161
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发表时间：
2018-02-01
影响因子：
7.7
通讯作者：
Louis, Germaine M. Buck
中科院分区：
文献类型：
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作者：
Grewal, Jagteshwar;Grantz, Katherine L.;Louis, Germaine M. Buck
最佳的胎儿生长是长期健康的基础，而异常生长会影响整个生命周期的疾病风险。胎儿生长受限和过度生长都与胎儿、婴儿和儿童死亡率和发病率增加有关，1，2也是生殖障碍和迟发性疾病的因素。人口层面的数据表明，出生体重减少与慢性疾病（包括高血压）之间存在关系，3，4支持健康和疾病研究范式的早期起源。5尽管胎儿生长发育的重要性，但超声测量胎儿生长发育的美国标准并不存在。现有的出生率参考文献描述了所有胎儿的出生体重的胎龄分布，包括生长受限的早产儿和糖尿病母亲的婴儿。6-8现有的超声参考文献通常是根据不代表美国人群的当地便利样本构建的。相反，超声标准可以有目的地制定，以反映最佳的增长，通过限制研究人群
Optimal fetal growth is a foundation for long-term health, whereas abnormal growth affects disease risk across the lifespan. Both fetal growth restriction and overgrowth are associated with increased fetal, infant and child mortality and morbidity, 1, 2 as well as being factors in reproductive disorders and later-onset diseases. Population-level data suggest a relationship between diminished birth size and chronic disorders, including hypertension, 3, 4 supporting the early origins of health and disease research paradigm. 5Despite the importance of adequate fetal growth, no US standards for ultrasound-measured fetal growth exist. Existing natality references describe the gestational age distribution of birthweight for all fetuses, including growth-restricted preterm infants and infants of diabetic mothers. 6–8 Existing ultrasound references have generally been constructed from local convenience samples which are not representative of the US population. In contrast, ultrasonographic standards can be purposefully developed to reflect optimal growth by restricting study populations