Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia
Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia
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DOI：
10.1016/j.schres.2014.12.023
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发表时间：
2015-03-01
影响因子：
4.5
通讯作者：
Buchanan, Robert W.
中科院分区：
文献类型：
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作者：
Strauss, Gregory P.;Keller, William R.;Buchanan, Robert W.
基础神经科学研究为催产素在啮齿动物嗅觉过程和社会关系中的作用提供了强有力的证据。考虑到嗅觉障碍与精神分裂症患者更严重的社交障碍有关的既往迹象，我们在门诊精神分裂症患者（n = 39）和人口统计学匹配的健康对照（n = 21）样本中研究了血浆催产素水平与嗅觉和社会结果测量之间的相关性。参与者完成了40项宾夕法尼亚大学气味识别测试（UPSIT），并对每种气味的积极和消极程度进行了评价。结果表明，与对照组相比，精神分裂症患者血浆催产素水平较高，UPSIT项目的总体准确性较低。精神分裂症患者也报告说，在对嗅觉刺激的反应中，他们比对照组经历了更多的负面情绪。较低的血浆催产素水平与精神分裂症患者对愉快和不愉快气味的准确性较差以及严重的社交障碍有关。这些结果表明，内源性催产素水平可能是一个重要的预测嗅觉识别缺陷和阴性症状的精神分裂症。(C)2015爱思唯尔B.V.保留所有权利。
Basic neuroscience research provides strong evidence for the role of oxytocin in olfactory processes and social affiliation in rodents. Given prior indication of olfactory impairments that are linked to greater severity of asociality in schizophrenia, we examined the association between plasma oxytocin levels and measures of olfaction and social outcome in a sample of outpatients with schizophrenia (n = 39) and demographically matched healthy controls (n = 21). Participants completed the 40-item University of Pennsylvania Smell Identification Test (UPSIT), and rated each odor for how positive and how negative it made them feel. Results indicated that individuals with schizophrenia had higher plasma oxytocin levels and lower overall accuracy for UPSIT items than controls. Individuals with schizophrenia also reported experiencing more negative emotionality than controls in response to the olfactory stimuli. Lower plasma oxytocin levels were associated with poorer accuracy for pleasant and unpleasant odors and greater severity of asociality in individuals with schizophrenia. These findings suggest that endogenous oxytocin levels may be an important predictor of olfactory identification deficits and negative symptoms in schizophrenia. (C) 2015 Elsevier B.V. All rights reserved.