The involvement of cell-to-cell signals in the development of a bacterial biofilm
The involvement of cell-to-cell signals in the development of a bacterial biofilm
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DOI：
10.1126/science.280.5361.295
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发表时间：
1998-04-10
期刊：
影响因子：
56.9
通讯作者：
Greenberg, EP
中科院分区：
文献类型：
--
作者：
Davies, DG;Parsek, MR;Greenberg, EP
自然界中的细菌通常以称为生物膜的固着群落形式存在。这些群落形成的结构在形态和生理上都与自由生活的细菌不同。细胞间信号参与铜绿假单胞菌生物膜的形成。一种特定的信号突变体，即lasl突变体，形成平坦的、未分化的生物膜，与野生型生物膜不同，它对杀菌剂十二烷基硫酸钠敏感。当在合成信号分子存在的情况下生长时，突变体生物膜显得正常。细胞间信号分子参与铜绿假单胞菌生物膜的形成，表明了控制导管上、囊性纤维化以及铜绿假单胞菌生物膜是一个持续问题的其他环境中生物膜生长的可能目标。
Bacteria in nature often exist as sessile communities called biofilms. These communities develop structures that are morphologically and physiologically differentiated from free-living bacteria. A cell-to-cell signal is involved in the development of Pseudomonas aeruginosa biofilms. A specific signaling mutant, a lasl mutant, forms flat, undifferentiated biofilms that unlike wild-type biofilms are sensitive to the biocide sodium dodecyl sulfate, Mutant biofilms appeared normal when grown in the presence of a synthetic signal molecule. The involvement of an intercellular signal molecule in the development of P. aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aeruginosa biofilms are a persistent problem.