The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease.
The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease.
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DOI：
10.18295/squmj.2015.15.03.002
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发表时间：
2015-08-01
影响因子：
--
通讯作者：
Mirshafiey, Abbas
中科院分区：
文献类型：
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作者：
Azizi, Gholamreza;Navabi, Shadi S;Mirshafiey, Abbas
阿尔茨海默病（AD）是一种与高龄相关的神经退行性疾病，是全球痴呆症最常见的原因。AD的特征在于认知功能障碍、淀粉样斑块沉积、神经纤维缠结和神经炎症。脑的炎症是AD的关键病理标志。因此，AD的临床和免疫病理学证据可能得到炎症介质的支持，包括细胞因子、趋化因子、补体系统、急性期蛋白和氧化介质。特别是，氧化介质可能会积极促进AD的进展和大脑中持续的炎症。本文就炎症介质在AD中的作用和活性作一综述。需要更好地理解炎症过程及其在AD中的作用，以提高AD和类似疾病领域的治疗研究目标。
Alzheimer's disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.