Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
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DOI：
10.1097/jto.0b013e31825aba47
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Wiencke JK
中科院分区：
文献类型：
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作者：
Bracci PM;Sison J;Hansen H;Walsh KM;Quesenberry CP;Raz DJ;Wrensch M;Wiencke JK
原位腺癌（AIS，以前称为细支气管肺泡癌 [BAC]）是肺腺癌的一种罕见亚型，约占肺癌的 3-4%。与其他肺癌组织学相比，AIS 病例吸烟者的可能性较小，但与其他肺癌危险因素的关联以及性别差异尚未确定。这些分析中纳入了来自母研究的总共 338 个 AIS（以前称为 BAC）病例和频率匹配的对照（病例 = 6039，对照 = 2073）。作为相对风险估计的优势比和 95% 置信区间是从多变量非条件逻辑回归分析中获得的。 AIS 风险与曾经吸烟有关（OR=2.7，95% CI：2.1，3.6），吸烟包数每增加 10 年，AIS 风险就会增加 20-30%，并且随着戒烟年数的增加而降低（趋势 P <0.0001）。没有证据表明风险因性别而异，但有一些建议表明，白人的风险可能因石棉和二手烟草烟雾暴露而异。 AIS 与吸烟之间的关联程度小于其他非小细胞肺癌亚型。我们的研究结果表明，石棉和二手烟草烟雾暴露的影响可能有所不同，应保守地解释，并需要在更大规模的 AIS 研究中进行验证和进一步评估。
Adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma [BAC]) is an uncommon subtype of lung adenocarcinoma and accounts for approximately 3–4% of lung cancers. Compared with other lung cancer histologies, AIS cases are less likely to be smokers, yet associations with other lung cancer risk factors and differences by gender have not been determined. A total of 338 AIS (formerly BAC) cases and frequency matched controls from the parent study (cases=6039, controls=2073) were included in these analyses. Odds ratios and 95% confidence intervals as estimates of the relative risk were obtained from multivariable unconditional logistic regression analyses. Risk of AIS was associated with ever smoking (OR=2.7, 95% CI: 2.1, 3.6), increased 20–30% for each 10-year increase in pack-years of smoking and decreased with increased years since quitting (P for trend <0.0001). There was no evidence that risk differed by gender but there was some suggestion that risk may differ by asbestos and by second-hand tobacco smoke exposure in whites. There is an association between AIS and smoking that is smaller in magnitude than other subtypes of non-small cell lung cancer. Our findings suggesting that effects may differ by asbestos and second-hand tobacco smoke exposure should be interpreted conservatively and warrant validation and further evaluation in larger studies of AIS.