HIV virological failure and drug resistance among injecting drug users receiving first-line ART in China.
HIV virological failure and drug resistance among injecting drug users receiving first-line ART in China.
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DOI：
10.1136/bmjopen-2014-005886
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发表时间：
2014-10-15
期刊：
影响因子：
2.9
通讯作者：
Shao Y
中科院分区：
文献类型：
--
作者：
Leng X;Liang S;Ma Y;Dong Y;Kan W;Goan D;Hsi JH;Liao L;Wang J;He C;Zhang H;Xing H;Ruan Y;Shao Y
目的探讨中国接受一线抗逆转录病毒治疗（ART）的注射吸毒者（IDUs）的HIV病毒学失败和耐药性。2003 - 2012年中国艾滋病病毒耐药性监测网络的一系列横断面调查。中国。数据由中国国家（HIVDR）监测和监测网络从2003年到2012年进行分析。包括人口统计、抗逆转录病毒治疗和实验室数据（CD4+细胞计数、病毒载量和耐药性）。通过逻辑回归分析确定与病毒学失败相关的因素。中国hiv - dr数据库中8556人中有929人接受了一线抗逆转录病毒治疗。对于这929例idu，中位治疗持续时间为14个月（IQR 6.0-17.8）。929例idu中有193例（20.8%）出现病毒学失败（HIV病毒载量≥1000拷贝/mL）。病毒学失败患者中HIVDR患病率为38.9%（68/175）。对非核苷类逆转录酶抑制剂（NNRTIs）、核苷类逆转录酶抑制剂（NRTIs）和蛋白酶抑制剂（PIs）耐药的患者比例分别为52.9%、76.5%和4.4%。与病毒学失败独立相关的因素包括：少数民族、初中及以下文化程度、农民、过去一个月自报缺失剂量、调查时CD4细胞计数在200 - 349细胞/mm3或0 - 199细胞/mm3之间，以及广西和云南的居住地。在中国接受一线抗逆转录病毒治疗的注射吸毒者中，病毒学失败的比例很高。然而，广西和云南的治疗效果较好，这表明ART教育和干预依从性的重要性，特别是对于农民、少数民族或教育背景较差的患者。
To explore HIV virological failure and drug resistance among injecting drug users (IDUs) receiving first-line antiretroviral treatment (ART) in China. A series of cross-sectional surveys from 2003 to 2012 from the Chinese National HIV Drug Resistance (HIVDR) Surveillance and Monitoring Network. China. Data were analysed by the Chinese National (HIVDR) Surveillance and Monitoring Network from 2003 to 2012. Demographic, ART and laboratory data (CD4+ cell count, viral load and drug resistance) were included. Factors associated with virological failure were identified by logistic regression analysis. 929 of the 8556 individuals in the Chinese HIVDR database were IDUs receiving first-line ART. For these 929 IDUs, the median duration of treatment was 14 months (IQR 6.0–17.8). 193 of the 929 IDUs (20.8%) experienced virological failure (HIV viral load ≥1000 copies/mL). The prevalence of HIVDR among patients with virological failure was 38.9% (68/175). The proportion of patients with drug resistance to non-nucleoside reverse transcriptase inhibitor (NNRTIs), nucleoside reverse transcriptase inhibitor (NRTIs) and protease inhibitors (PIs) was 52.9%, 76.5% and 4.4%, respectively. Factors independently associated with virological failure include: ethnic minorities, junior high school education or less, farmers, self-reported missing doses in the past month, CD4 cell count at survey from 200 to 349 cells/mm3 or from 0 to 199 cells/mm3, and residence of Guangxi and Yunnan provinces. The proportion of virological failure was high among IDUs receiving first-line ART in China. However, better treatment outcomes were observed in Guangxi and Yunnan, which indicates the importance of ART education and adherence to intervention, especially for patients who are farmers, minorities or have a poor educational background.
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DOI：
10.1186/1747-597x-9-11
发表时间：
2014-02-24
期刊：
Substance abuse treatment, prevention, and policy
影响因子：
--
作者：
Jiang H;Han Y;Du J;Wu F;Zhang R;Zhang H;Wang J;Zhou Z;Hser YI;Zhao M
通讯作者：
Zhao M
影响因子：
4.9
作者：
Waldrop-Valverde, D;Valverde, E
通讯作者：
Valverde, E
影响因子：
3.3
作者：
Ruan, Yuhua;Xing, Hui;Shao, Yiming
通讯作者：
Shao, Yiming
影响因子：
6
作者：
Wisaksana, Rudi;Indrati, Agnes K.;van Crevel, Reinout
通讯作者：
van Crevel, Reinout
影响因子：
--
作者：
Patel D;Desai M;Shah AN;Dikshit RK
通讯作者：
Dikshit RK