Innovative Point-of- Care (POC) Micro Biochip for Early Stage Ovarian Cancer Diagnostics
Innovative Point-of- Care (POC) Micro Biochip for Early Stage Ovarian Cancer Diagnostics
复制标题
用于早期卵巢癌诊断的创新护理点 (POC) 微型生物芯片
DOI：
10.1002/9780470015902.a0026245
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Eon Soo Lee
中科院分区：
文献类型：
--
作者：
B. Nunna;D. Mandal;S. Zhuang;Eon Soo Lee
大多数癌症如果在早期发现是可以治愈的。癌症的早期检测可以显着改善患者的治疗结果，从而有助于减少癌症的发生。为了实现特定癌症的早期检测，生物芯片结合了创新的传感机制和表面处理的微通道。护理点（POC）生物芯片中采用的传感机制被设计为高度特异性和灵敏度。表面处理的微通道有助于控制血液样品的自驱动流动。具有增强的特异性和亲和力的癌症抗体被固定在微通道中的纳米电路的表面上。当血液样品在微通道中流过癌抗体时，来自血液的相应癌抗原形成抗原-抗体复合物。这些抗原-抗体相互作用被捕获的金纳米电路使用生物芯片中的传感机制的电性能的变化。护理点（POC）微生物芯片被设计为一种原位独立设备，通过检测从手指穿刺中抽取的血液样本中的癌抗原，在早期诊断卵巢癌。POC生物芯片可以利用生物芯片中传感机制的定性和定量结果来帮助诊断癌症的存在及其严重程度。
Most of the cancers are curable if they are detected at early stages. The early stage detection of cancers can significantly improve the patient treatment outcomes and thus helps to decrease the. To achieve the early detection of specific cancer, the biochip is incorporated with an innovative sensing mechanism and surface treated microchannels. The sensing mechanism employed in the Point of Care (POC) biochip is designed to be highly specific and sensitive. The surface treated microchannel helps to control the self-driven flow of the blood sample. Cancer antibodies with enhanced specificity and affinity are immobilized on the surface of the nano circuit in the microchannel. When the blood sample flows in the microchannel over the cancer antibodies, the corresponding cancer antigens from the blood form the antigen-antibody complex. These antigen-antibody interactions are captured with the variation in the electrical properties of the gold nano circuit using the sensing mechanism in the biochip. The point of care (POC) micro biochip is designed as an in-situ standalone device to diagnose ovarian cancer at the early stages by sensing the cancer antigens in the blood sample drawn from a finger prick. The POC biochip can help to diagnose, the existence of cancer and also its severity using the qualitative and the quantitative results of the sensing mechanism in the biochip.
影响因子：
4.7
作者：
Moore, Richard G.;Brown, Amy K.;Bast, Robert C., Jr.
通讯作者：
Bast, Robert C., Jr.
DOI：
10.1093/jnci/93.19.1458
发表时间：
2001-10-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Mok, SC;Chao, J;Cramer, DW
通讯作者：
Cramer, DW