Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats
Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats
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DOI：
10.1016/s0304-3940(02)01101-1
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发表时间：
2002-11-29
影响因子：
2.5
通讯作者：
Dixon, CE
中科院分区：
文献类型：
--
作者：
Kline, AE;Yu, JY;Dixon, CE
为了进一步研究 5-HT1A 受体激动剂对脑外伤 (TBI) 大鼠功能和组织学结果的功效，在受控皮质撞击或假损伤后 15 分钟，腹腔内单次注射 8-羟基-2-(二正丙氨基)四氢萘 (8-OH-DPAT；0.1、0.5 或 1.0 mg/kg) 或载体。分别在术后第 1-5 天和第 14-18 天通过既定的运动和认知测试评估功能。 4 周时对皮质病变体积和海马 CA(1)/CA(3) 细胞存活率进行定量。与载体相比，施用 8-OH-DPAT (0.5 mg/kg) 可减轻空间获取缺陷并减少海马 CA(3) 细胞损失 (P < 0.05)。这些数据补充了已发表的报告，即 5-HT1A 受体激动剂在实验性 TBI 后具有神经保护作用。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
To further investigate the efficacy of 5-HT1A receptor agonism on functional and histological outcome in traumatically-brain injured (TBI) rats, a single intraperitoneal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.1, 0.5, or 1.0 mg/kg) or vehicle was given 15 min after controlled cortical impact or sham injury. Function was assessed by established motor and cognitive tests on post-operative days 1-5 and 14-18, respectively. Cortical lesion volume and hippocampal CA(1)/CA(3) cell survival were quantified at 4 weeks. The administration of 8-OH-DPAT (0.5 mg/kg) attenuated spatial acquisition deficits and reduced hippocampal CA(3) cell loss vs. vehicle (P < 0.05). These data augment published reports that 5-HT1A receptor agonists confer neuroprotective effects after experimental TBI. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.