EFFECTS OF SINGLE AND REPEATED DOSES OF OMEPRAZOLE ON GASTRIC-ACID AND PEPSIN-SECRETION IN MAN
EFFECTS OF SINGLE AND REPEATED DOSES OF OMEPRAZOLE ON GASTRIC-ACID AND PEPSIN-SECRETION IN MAN
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DOI：
10.1136/gut.25.7.707
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发表时间：
1984-01-01
期刊：
影响因子：
24.5
通讯作者：
REID, JL
中科院分区：
文献类型：
--
作者：
HOWDEN, CW;FORREST, JAH;REID, JL
本文研究了取代苯并咪唑的奥美拉唑对12名健康受试者胃酸和胃酶分泌的影响。单次口服30 mg后6~8h，基础胃酸排出量减少66%，五肽胃泌素刺激排酸减少71.2%。单剂量60毫克可使基础胃酸产量减少91.7%，五肽胃泌素刺激的胃酸产量减少95.3%。每天服用30或60毫克的药物治疗7天后，基础胃泌素和五肽胃泌素刺激的胃酸分泌几乎100%被抑制。作为壁细胞分泌膜上H+/K+-ATPase酶的抑制剂，奥美拉唑对胃酶的分泌没有明显的影响，这与其所提出的作用模式是一致的。奥美拉唑单次给药或重复给药均未见副作用。
The effects of omeprazole, a substituted benzimidazole, on gastric acid and pepsin secretion were studied in 12 healthy subjects. From 6-8 h after a single oral dose of 30 mg, there was a 66% reduction in basal acid output and a 71.2% reduction in pentagastrin stimulated acid output. A single dose of 60 mg produced a 91.7% reduction in basal acid output and a 95.3% reduction in pentagastrin-stimulated acid output. After 7 days treatment with 30 or 60 mg daily, there was almost 100% inhibition of both basal and pentagastrin-stimulated acid output. Omeprazole did not significantly affect pepsin secretion which is in keeping with its proposed mode of action, as an inhibitor of the H+/K+-ATPase enzyme on the secretory membrane of the parietal cell. There were no side effects after omeprazole either with single or repeated dosing.