Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III
Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III
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DOI：
10.1248/cpb.c16-00037
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发表时间：
2016-07-01
影响因子：
1.7
通讯作者：
Kawabata, Takeo
中科院分区：
文献类型：
--
作者：
Yanagi, Masanori;Ninomiya, Ryo;Kawabata, Takeo
10-去乙酰基浆果赤霉素III是紫杉醇半合成的关键天然产物，已实现有机催化位点选择性多样化。将各种酰基选择性地引入10-脱乙酰基浆果赤霉素III的C（10）-OH中。C（10）-OH选择性酰化也适用于10-脱乙酰基浆果赤霉素III的酰化位点选择性二聚，以提供结构确定的二聚体。
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.