Prenatal depressive symptoms and abnormalities of glucose tolerance during pregnancy among Hispanic women
Prenatal depressive symptoms and abnormalities of glucose tolerance during pregnancy among Hispanic women
复制标题
DOI：
10.1007/s00737-013-0379-2
复制
发表时间：
2014-02-01
影响因子：
4.5
通讯作者：
Chasan-Taber, Lisa
中科院分区：
文献类型：
--
作者：
Ertel, Karen A.;Silveira, Marushka;Chasan-Taber, Lisa
本研究的目的是前瞻性地研究孕妇在怀孕早期的抑郁症状与妊娠中期糖耐量异常（AGT）和糖耐量受损（IGT）风险之间的关系。我们评估了934名参与Proyecto Buena Salud的参与者之间的这种关联，这是一项针对马萨诸塞州西部西班牙裔（主要是波多黎各人）妇女的前瞻性队列研究。抑郁症状进行了评估，在怀孕早期使用10项爱丁堡产后抑郁量表。分数为千分之一日元13表示至少可能有轻度抑郁症，分数为千分之一日元15表示可能有重度抑郁症。采用美国糖尿病协会标准诊断AGT和IGT。在怀孕早期，247名（26.5%）参与者至少经历了轻度抑郁，163名（17.4%）经历了重度抑郁。AGT 123例（13.2%），IGT 56例（6.0%）.在完全校正的模型中，AGT与轻度抑郁症相关的比值比为1.20（95%CI 0.77-1.89），与重度抑郁症相关的比值比为1.34（95%CI 0.81-2.23）。IGT与轻度抑郁症相关的比值比为1.22（95%CI 0.62-2.40），与重度抑郁症相关的比值比为1.53（95%CI 0.73-3.22）.我们没有观察到与连续筛查血糖指标的相关性。西班牙裔女性的前瞻性队列研究结果表明，妊娠早期轻度或重度抑郁与AGT或妊娠中期筛查血糖值之间无统计学显著相关性。由于IGT病例数量较少，我们评估抑郁症和IGT风险之间关系的能力受到限制。
The aim of this study is to prospectively examine the association between maternal depressive symptoms in early pregnancy and risk of abnormal glucose tolerance (AGT) and impaired glucose tolerance (IGT) in mid-pregnancy. We evaluated this association among 934 participants in Proyecto Buena Salud, a prospective cohort study of Hispanic (predominantly Puerto Rican) women in Western Massachusetts. Depressive symptoms were assessed in early pregnancy using the 10-item Edinburgh Postnatal Depression Scale. Scores a parts per thousand yen13 indicated at least probable minor depression and scores a parts per thousand yen15 indicated probable major depression. AGT and IGT were diagnosed using American Diabetes Association criteria. In early pregnancy, 247 (26.5 %) participants experienced at least minor depression and 163 (17.4 %) experienced major depression. A total of 123 (13.2 %) were classified with AGT and 56 (6.0 %) were classified with IGT. In fully-adjusted models, the odds ratio for AGT associated with minor depression was 1.20 (95 % CI 0.77-1.89) and for major depression was 1.34 (95 % CI 0.81-2.23). The odds ratio for IGT associated with minor depression was 1.22 (95 % CI 0.62-2.40) and for major depression was 1.53 (95 % CI 0.73-3.22). We did not observe an association with continuous screening glucose measures. Findings in this prospective cohort of Hispanic women did not indicate a statistically significant association between minor or major depression in early pregnancy and AGT or screening glucose values in mid-pregnancy. Due to the small number of cases of IGT, our ability to evaluate the association between depression and IGT risk was constrained.