First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours.
First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours.
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DOI：
10.1038/sj.bjc.6603445
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发表时间：
2006-12-18
影响因子：
8.8
通讯作者：
Vermeulen, P B
中科院分区：
文献类型：
--
作者：
Van der Auwera, I;Cao, Y;Tille, J C;Pepper, M S;Jackson, D G;Fox, S B;Harris, A L;Dirix, L Y;Vermeulen, P B
淋巴系统是大多数人类癌症转移的主要途径。最近研究淋巴管生成的研究工作表明淋巴管密度与患者生存之间存在关系。然而，目前淋巴管生成定量方法的特点仍然是观察者内部和观察者之间的高度变异性。为了使肿瘤中的淋巴管数量成为临床上有用的参数，需要开发可靠的量化技术。因此，通过这份共识报告，我们希望开始讨论淋巴管生成评估的免疫组织化学方法的标准化。
The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment.