Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
复制标题
DOI：
10.1186/s40463-015-0091-5
复制
发表时间：
2015-09-15
影响因子：
3.4
通讯作者：
Biron, Vincent L.
中科院分区：
文献类型：
--
作者：
Clark, Jessica;Jeffery, Caroline C.;Biron, Vincent L.
背景：近年来，人乳头瘤病毒（HPV）相关口咽鳞状细胞癌（OPSCC）的发病率呈上升趋势。鉴于HPV/p16阳性在OPSCC中的临床影响，在这些患者的诊断检查中早期识别这种疾病的替代标志物可以改善患者的护理。方法：从前瞻性收集的省级癌症登记处获得2009-2014年诊断为OPSCC的患者的人口学、病理、分期和PET-CT数据。肿瘤HPV/p16状态与原发肿瘤和宫颈结的最大标准摄取值（SUVmax）相关。采用均值和多项回归模型的比较来确定p16状态与SUVmax之间的关系。基于节点SUVmax，使用预测HPV/p16阳性的截断值计算诊断优势比。结果：获得了65例手术治疗的OPSCC患者的PET-CT和HPV/p16数据。较高的结节SUVmax与HPV/p16阳性淋巴结相关（SUVmax 10.8 vs 7.9）。HPV/p16阳性与阴性原发肿瘤SUVmax无显著差异（10.3 vs 13.7）。结合其他临床参数，较高的淋巴结SUVmax与HPV/p16阳性高度相关。结论：淋巴结SUVmax升高是HPV/p16阳性疾病的重要预测因子。
Background: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has been rising in recent years. Given the clinical impact of HPV/p16 positivity in OPSCC, identifying surrogate markers of this disease early in the diagnostic work-up of these patients could improve patient care.Methods: Demographic, pathologic, staging and PET-CT data from patients diagnosed with OPSCC from 2009-2014 were obtained from a prospectively collected provincial cancer registry. Tumor HPV/p16 status was correlated to the maximum standard uptake value (SUVmax) of the primary tumor and cervical nodes. Comparisons of means and multinomial regression models were used to determine associations between p16 status and SUVmax. A diagnostic odds ratio was calculated using a cut off value for predicting HPV/p16 positivity based on nodal SUVmax.Results: PET-CT and HPV/p16 data was obtained for 65 patients treated surgically for OPSCC. Significantly higher nodal SUVmax was associated with HPV/p16 positive nodes (SUVmax 10.8 vs 7.9). No significant differences were seen between HPV/p16 positive vs negative primary tumor SUVmax (10.3 vs 13.7). In combination with other clinical parameters, higher nodal SUVmax was highly correlated with HPV/p16 positivity.Conclusion: Elevated nodal SUVmax is a significant predictor of HPV/p16 positive disease.