Characterization of the piRNA complex from rat testes
Characterization of the piRNA complex from rat testes
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DOI：
10.1126/science.1130164
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发表时间：
2006-07-21
期刊：
影响因子：
56.9
通讯作者：
Kingston, Robert E.
中科院分区：
文献类型：
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作者：
Lau, Nelson C.;Seto, Anita G.;Kingston, Robert E.
小的非编码RNA调节细胞生长和发育所必需的过程，包括mRNA降解、翻译抑制和转录基因沉默（TGS）。在寻找TGS的候选哺乳动物因子的过程中，我们纯化了一种含有小RNA和Riwi的复合物，Riwi是人类Piwi的大鼠同源物。这些RNA通常长度为29至30个核苷酸，被称为Piwi相互作用RNA（piRNA），其中94%的RNA映射到100个定义的（
Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search for candidate mammalian factors for TGS, we purified a complex that contains small RNAs and Riwi, the rat homolog to human Piwi. The RNAs, frequently 29 to 30 nucleotides in length, are called Piwi-interacting RNAs (piRNAs), 94% of which map to 100 defined (