High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma.
High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma.
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DOI：
10.1038/sj.bjc.6605020
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发表时间：
2009-05-05
影响因子：
8.8
通讯作者：
Van Laethem, J-L
中科院分区：
文献类型：
--
作者：
Marechal, R.;Demetter, P.;Nagy, N.;Berton, A.;Decaestecker, C.;Polus, M.;Closset, J.;Deviere, J.;Salmon, I.;Van Laethem, J-L
趋化因子及其受体参与胰腺腺癌（PA）的致瘤性，趋化因子受体表达的临床病理意义尚不完全清楚。本研究通过观察PA切除术后CXCR4、CXCR7和HIF-1α的表达来判断患者的预后。采用组织芯片技术对71例切除（R0） PA及其48例相关淋巴结（LN）进行CXCR4、CXCR7、HIF-1α表达及细胞增殖指数（Ki-67）的免疫组化检测。CXCR4和CXCR7的表达与HIF-1α呈正相关，提示HIF-1α在CXCR4和CXCR7转录激活中的潜在作用。cxcr4高表达患者的生存期比低表达患者短（中位生存期：9.7个月vs 43.2个月，P=0.0006）， LN转移和肝脏复发的风险更高。在多因素分析中，CXCR4高表达、淋巴结转移和低分化肿瘤是独立的不良预后因素。在一项综合分析中，CXCR4low/CXCR7low肿瘤患者的DFS和OS明显短于CXCR7high/CXCR4high肿瘤患者。切除PA中的CXCR4可能是一个有价值的预后因素，也是一个有吸引力的治疗靶点。
Chemokines and their receptors are involved in tumourigenicity and clinicopathological significance of chemokines receptor expression in pancreatic adenocarcinoma (PA) is not fully understood. This study was conducted to determine patients' outcome according to the expressions of CXCR4, CXCR7 and HIF-1α after resection of PA. Immunohistochemistry for CXCR4, CXCR7 and HIF-1α expressions as well as cell proliferative index (Ki-67) was conducted in 71 resected (R0) PA and their 48 related lymph nodes (LN) using tissue microarray. CXCR4 and CXCR7 expressions were positively correlated to HIF-1α suggesting a potential role of HIF-1α in CXCR4 and CXCR7 transcription activation. Patients with CXCR4high tumour expression had shorter OS than those with low expression (median survival: 9.7 vs 43.2 months, P=0.0006), a higher risk of LN metastases and liver recurrence. In multivariate analysis, high CXCR4 expression, LN metastases and poorly differentiated tumour are independent negative prognosis factors. In a combining analysis, patients with CXCR4low/CXCR7low tumour had a significantly shorter DFS and OS than patients with a CXCR7high/CXCR4high tumour. CXCR4 in resected PA may represent a valuable prognostic factor as well as an attractive target for therapeutic purpose.
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通过缺氧对趋化因子受体CXCR4的调节。
DOI：
10.1084/jem.20030267
发表时间：
2003-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
11.2
作者：
Marchesi, F;Monti, P;Allavena, P
通讯作者：
Allavena, P
影响因子：
29.4
作者：
Saur, D;Seidler, B;Schmid, RM
通讯作者：
Schmid, RM
影响因子：
8
作者：
Burger, M;Glodek, A;Burger, JA
通讯作者：
Burger, JA
影响因子：
--
作者：
Dambly-Chaudière C;Cubedo N;Ghysen A
通讯作者：
Ghysen A