Risk factors for EEG seizures in neonates treated with hypothermia A multicenter cohort study
Risk factors for EEG seizures in neonates treated with hypothermia A multicenter cohort study
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DOI：
10.1212/wnl.0000000000000282
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发表时间：
2014-04-08
期刊：
影响因子：
9.9
通讯作者：
Chang, Taeun
中科院分区：
文献类型：
--
作者：
Glass, Hannah C.;Wusthoff, Courtney J.;Chang, Taeun
目的：探讨新生儿缺氧缺血性脑病（hypoxic-ischemic encephalopathy，HIE）低温治疗后电描记癫痫发作的危险因素。方法：对90例足月新生儿进行三中心观察性队列研究，采用连续视频脑电图（cEEG）监测新生儿出生后第1天内（记录开始时的中位年龄为9.5小时，四分位数间距为6.3-14.5），并持续监测>24小时（总记录时间为93.3小时，存活者的四分位数间距为80.1-112.8）。在每个站点的小儿脑电图检查cEEG的脑电图癫痫发作和初始EEG的背景category.Results：共43（48%）有脑电图癫痫发作，包括9（10%）与脑电图癫痫持续状态。异常的初始EEG背景分类（过度不连续、抑郁和未分化、爆发抑制或极低电压），但不是临床变量（包括pH
Objective:To assess the risk factors for electrographic seizures among neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE).Methods:Three-center observational cohort study of 90 term neonates treated with hypothermia, monitored with continuous video-EEG (cEEG) within the first day of life (median age at onset of recording 9.5 hours, interquartile range 6.3-14.5), and continued for >24 hours (total recording 93.3 hours, interquartile range 80.1-112.8 among survivors). A pediatric electroencephalographer at each site reviewed cEEGs for electrographic seizures and initial EEG background category.Results:A total of 43 (48%) had electrographic seizures, including 9 (10%) with electrographic status epilepticus. Abnormal initial EEG background classification (excessively discontinuous, depressed and undifferentiated, burst suppression, or extremely low voltage), but not clinical variables (including pH