Risk of dementia among white and African American relatives of patients with Alzheimer disease
Risk of dementia among white and African American relatives of patients with Alzheimer disease
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DOI：
10.1001/jama.287.3.329
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发表时间：
2002-01-16
影响因子：
120.7
通讯作者：
Farrer, LA
中科院分区：
文献类型：
--
作者：
Green, RC;Cupples, LA;Farrer, LA
背景证据表明，阿尔茨海默病(AD)的发病率以及可归因于特定遗传因素(如载脂蛋白E(APOE)基因)的风险在不同种族之间可能有很大差异。对阿尔茨海默病先证者的家系研究为评估这些先证者亲属的终生痴呆症风险提供了机会。目的比较可能患有或明确患有痴呆症的白人和非裔美国人先证者亲属的终生痴呆症风险估计。设计和建立风险分析使用1991年5月至2001年3月在17个医学中心通过问卷和补充记录收集的数据，这些医学中心参与了阿尔茨海默病遗传流行病学研究的多机构研究。共有2 339名白人先证者的17639名一级生物亲属和2 474名配偶，以及255名非洲裔美国AD先证者的2 281名一级生物亲属和257名配偶进行了风险分析。主要结果衡量按85岁计算的痴呆症累积风险，结果非裔美国人AD先证者一级亲属85岁时痴呆的累积危险度为43.7%(SE，3.1%)，白人AD先证者一级生物学亲属85岁时痴呆的累积危险度为26.9%(SE，0.8%)，相对危险度(RR)为1.6(95%可信区间[CI]，1.4~1.9；P
Context Evidence exists that the incidence of Alzheimer disease (AD), as well as risk attributable to specific genetic factors such as apolipoprotein E (APOE) genotype, may vary considerably among ethnic groups. Family studies of probands with AD offer an opportunity to evaluate lifetime risk of dementia among relatives of these probands.Objective To compare lifetime dementia risk estimates among relatives of white and African American probands with probable or definite AD.Design and Setting Risk analysis using data collected by questionnaire and supplemental records between May 1991 and March 2001 at 17 medical centers contributing to the Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study.Participants A total of 17639 first-degree biological relatives and 2474 spouses of 2339 white AD probands, and 2281 first-degree biological relatives and 257 spouses of 255 African American AD probands.Main Outcome Measures Cumulative risk of dementia by age 85 years, stratified by ethnicity and sex of relatives and by APOE genotype of probands.Results Cumulative risk of dementia in first-degree biological relatives of African American AD probands by age 85 years was 43.7% (SE, 3.1%), and the corresponding risk in first-degree biological relatives of white AD probands was 26.9% (SE, 0.8%), yielding a relative risk (RR) of 1.6 (95% confidence interval [CI], 1.4-1.9; P