Spectroscopic and histological evaluation of wound healing progression following Low Level Laser Therapy (LLLT)
Spectroscopic and histological evaluation of wound healing progression following Low Level Laser Therapy (LLLT)
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DOI：
10.1002/jbio.201100089
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发表时间：
2012-02-01
影响因子：
2.8
通讯作者：
Mahato, Krishna K.
中科院分区：
文献类型：
--
作者：
Prabhu, Vijendra;Rao, Satish B. S.;Mahato, Krishna K.
本研究利用激光诱导荧光（LIF）和光学显微镜技术观察He-Ne激光对瑞士白化小鼠创面肉芽组织胶原合成的影响，以评价He-Ne激光对组织再生的影响。伤口肉芽组织的光谱分析表明，在受伤后几天胶原蛋白水平的剂量依赖性增加。另一方面，组织学检查也显示，与未照射的对照组相比，最佳激光剂量治疗组的胶原沉积显著增加，水肿减少，白细胞减少，肉芽组织增加，成纤维细胞数量增加。(C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
The present study focuses on the evaluation of the effect of He-Ne laser on tissue regeneration by monitoring collagen synthesis in wound granulation tissues in Swiss albino mice using analysis of laser induced fluorescence (LIF) and light microscopy techniques. The spectral analyses of the wound granulation tissues have indicated a dose dependent increase in collagen levels during the post-wounding days. The histological examinations on the other hand have also shown a significant increase in collagen deposition along with the reduced edema, leukocytes, increased granulation tissue, and fibroblast number in the optimal laser dose treated group compared to the non-illuminated controls. (C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)