Invited. Interactive MRI‐guided radiofrequency interstitial thermal ablation of abdominal tumors: Clinical trial for evaluation of safety and feasibility
Invited. Interactive MRI‐guided radiofrequency interstitial thermal ablation of abdominal tumors: Clinical trial for evaluation of safety and feasibility
复制标题
受邀请的交互式 MRI 引导腹部肿瘤射频间质热消融：评估安全性和可行性的临床试验
DOI：
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发表时间：
1999
影响因子：
4.4
通讯作者：
J. Haaga
中科院分区：
文献类型：
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作者：
J. Lewin;C. Connell;J. Duerk;Yiu;M. Clampitt;Julie Spisak;G. S. Gazelle;J. Haaga
本临床试验旨在评价完全在MR成像仪内进行的交互式MR引导射频（RF）间质热消融（ITA）的安全性和可行性。在13次治疗中，对11例腹腔内转移性肿瘤进行了RF‐ITA。使用稳态进动（FISP）快速成像和真实FISP图像，在MR引导下将射频电极放置在.2-T系统上。使用了定制的17 G电极，并在四个疗程中进行了修改，以允许在消融过程中循环冰盐水进行冷却。组织坏死监测和电极重新定位基于快速T2加权和短反转时间反转恢复（STIR）序列。通过临床和影像学标准评估死亡率和毒性。经治疗的所有11个肿瘤中均可见组织破坏区域，这在随后的对比增强图像中得到证实。未观察到显著的发病率，患者不适极轻微。总之，交互式MR引导RF‐ITA在临床0.2 T C形臂系统上是可行的，配有辅助介入附件，患者发病率很低。RF‐ITA完全消融肿瘤的能力取决于肿瘤大小和血管分布。
This clinical trial was performed to evaluate the safety and feasibility of interactive MR‐guided radiofrequency (RF) interstitial thermal ablation (ITA) performed entirely within the MR imager. RF‐ITA was performed on 11 intra‐abdominal metastatic tumors during 13 sessions. The RF electrode was placed under MR guidance on a .2‐T system using rapid fast imaging with steady state precession (FISP) and true FISP images. A custom 17‐gauge electrode was used and was modified in four sessions to allow circulation of iced saline for cooling during ablation. Tissue necrosis monitoring and electrode repositioning were based on rapid T2‐weighted and short‐inversion‐time inversion recovery (STIR) sequences. Morbidity and toxicity were assessed by clinical and imaging criteria. The region of tissue destruction was visible in all 11 tumors treated, as confirmed on subsequent contrast‐enhanced images. No significant morbidity was noted, and patient discomfort was minimal. In conclusion, interactive MR‐guided RF‐ITA is feasible on a clinical .2‐T C‐arm system with supplemental interventional accessories with only minor patient morbidity. The ability to completely ablate tumors with RF‐ITA depends on tumor size and vascularity.